Stanghellini Vincenzo, Tosetti Cesare, Barbara Giovanni, De Giorgio Roberto, Cogliandro Laura, Cogliandro Rosanna, Corinaldesi Roberto
Department of Internal Medicine, S. Orsola-Malpighi University Hospital, Bologna, Italy.
Am J Gastroenterol. 2002 Nov;97(11):2738-43. doi: 10.1111/j.1572-0241.2002.07062.x.
Irritable bowel syndrome (IBS) and dyspepsia often overlap. Delayed gastric emptying has been reported in IBS patients, although conflicting results exist. Whether overlapping dyspepsia correlates with gastric emptying abnormalities in IBS patients has not been clarified. This study aimed to evaluate gastric emptying of solids and its relationship with dyspeptic symptoms in IBS patients.
A total of 146 IBS outpatients seen in a referral center were evaluated for dyspeptic symptoms using a validated questionnaire. Gastric emptying of solids was evaluated scintigraphically in all patients and in 50 healthy controls.
Overlapping dyspepsia was diagnosed in 96 (66%) IBS patients. On average, gastric emptying rates were lower in IBS patients (mean +/- SEM, 33% +/- 1%/h) compared with controls (40% +/- 2%/h; p < 0.01). Specifically, gastric emptying was delayed in IBS patients with overlapping dyspepsia (31% +/- 1%/h; p < 0.01), whereas IBS patients without dyspeptic complaints showed gastric emptying rates (37% +/- 2%/h) that were similar to those of healthy controls (40% +/- 2%/h). Relevant postprandial fullness (OR = 4.7, 95% CI = 1.8-12.5) and relevant nausea (OR = 3.3, 95% CI 1.2-9.3) were independently associated with delayed gastric emptying.
IBS patients without overlapping dyspepsia have normal gastric emptying of solids. A significant association exists in IBS patients between delayed gastric emptying and overlapping relevant postprandial fullness and nausea.
肠易激综合征（IBS）与消化不良常相互重叠。尽管存在相互矛盾的结果，但已有报道称IBS患者存在胃排空延迟。IBS患者中重叠性消化不良是否与胃排空异常相关尚不清楚。本研究旨在评估IBS患者固体食物的胃排空情况及其与消化不良症状的关系。
使用经过验证的问卷对转诊中心的146例IBS门诊患者的消化不良症状进行评估。对所有患者及50名健康对照者进行固体食物胃排空的闪烁扫描评估。
96例（66%）IBS患者被诊断为重叠性消化不良。平均而言，IBS患者的胃排空率（均值±标准误，33%±1%/小时）低于对照组（40%±2%/小时；p<0.01）。具体而言，有重叠性消化不良的IBS患者胃排空延迟（31%±1%/小时；p<0.01），而无消化不良症状的IBS患者胃排空率（37%±2%/小时）与健康对照组（40%±2%/小时）相似。餐后相关饱腹感（比值比=4.7，95%置信区间=1.8-12.5）和相关恶心（比值比=3.3，95%置信区间1.2-9.3）与胃排空延迟独立相关。
无重叠性消化不良的IBS患者固体食物胃排空正常。IBS患者中胃排空延迟与餐后相关饱腹感和恶心重叠之间存在显著关联。
