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微生物基因组间横向基因转移的检测。

Detection of lateral gene transfer among microbial genomes.

作者信息

Ragan M A

机构信息

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.

出版信息

Curr Opin Genet Dev. 2001 Dec;11(6):620-6. doi: 10.1016/s0959-437x(00)00244-6.

Abstract

An increasingly comprehensive assessment is being developed of the extent and potential significance of lateral gene transfer among microbial genomes. Genomic sequences can be identified as being of putatively lateral origin by their unexpected phyletic distribution, atypical sequence composition, differential presence or absence in closely related genomes, or incongruent phylogenetic trees. These complementary approaches sometimes yield inconsistent results. Not only more data but also quantitative models and simulations are needed urgently.

摘要

对微生物基因组间横向基因转移的程度及其潜在重要性的评估正变得越来越全面。基因组序列可通过其意外的系统发育分布、非典型的序列组成、在密切相关基因组中的差异存在或缺失,或不一致的系统发育树,被鉴定为可能是横向起源的。这些互补的方法有时会产生不一致的结果。迫切需要的不仅是更多的数据,还有定量模型和模拟。

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