Song S, Abbott L F
Volen Center for Complex Systems and Department of Biology, Brandeis University, Waltham, MA 02454-9110, USA.
Neuron. 2001 Oct 25;32(2):339-50. doi: 10.1016/s0896-6273(01)00451-2.
Long-term modification of synaptic efficacy can depend on the timing of pre- and postsynaptic action potentials. In model studies, such spike timing-dependent plasticity (STDP) introduces the desirable features of competition among synapses and regulation of postsynaptic firing characteristics. STDP strengthens synapses that receive correlated input, which can lead to the formation of stimulus-selective columns and the development, refinement, and maintenance of selectivity maps in network models. The temporal asymmetry of STDP suppresses strong destabilizing self-excitatory loops and allows a group of neurons that become selective early in development to direct other neurons to become similarly selective. STDP, acting alone without further hypothetical global constraints or additional forms of plasticity, can also reproduce the remapping seen in adult cortex following afferent lesions.
突触效能的长期改变可能取决于突触前和突触后动作电位的时间。在模型研究中，这种依赖于尖峰时间的可塑性（STDP）引入了突触间竞争以及突触后放电特征调节等理想特性。STDP增强了接收相关输入的突触，这可能导致在网络模型中形成刺激选择性柱以及选择性图谱的发育、细化和维持。STDP的时间不对称性抑制了强烈的不稳定自激回路，并允许一组在发育早期就具有选择性的神经元引导其他神经元变得同样具有选择性。仅靠STDP自身，无需进一步假设的全局约束或其他形式的可塑性，也能够重现成年皮质在传入性损伤后出现的重新映射。
