来自乳头黄杨的乙酰胆碱酯酶和丁酰胆碱酯酶抑制三萜生物碱

Acetyl and butyrylcholinesterase-inhibiting triterpenoid alkaloids from Buxus papillosa.

作者信息

Parveen S, Khalid A, Farooq A, Choudhary M I

机构信息

H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, -75270, Karachi, Pakistan.

出版信息

Phytochemistry. 2001 Nov;58(6):963-8. doi: 10.1016/s0031-9422(01)00332-6.

DOI:10.1016/s0031-9422(01)00332-6

PMID:11684196

Abstract

Three triterpenoid alkaloids, buxakashmiramine [(20S)-20-dimethylamino-4',6'-dimethoxy-5'-hydroxybenzoylamino-3beta-methyl-buxan-31-ol] (1), buxakarachiamine [(20S)-20-dimethylamino-2'-hydroxy-3beta-methyl-3'-methyl-butanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] (2) and buxahejramine [(20S)-20-dimethylamino-2'-hydroxy-3beta-methyl-3'-methyl-pentanoylamino-9,10-seco-buxa-9(11), 10(19)-dien-31-ol] (3) were isolated from the leaves of Buxus papillosa. Four known bases, cycloprotobuxine-C (4), cyclovirobuxeine-A (5), cyclomicrophylline-A (6) and semperviraminol (7) were isolated for the first time from this species. Their structures were established through extensive spectroscopic studies. Most of these compounds exhibited anticholinesterase activity.

摘要

从乳头黄杨的叶子中分离出三种三萜生物碱，即布沙克什米尔胺[（20S）-20-二甲基氨基-4'，6'-二甲氧基-5'-羟基苯甲酰氨基-3β-甲基-布沙烷-31-醇]（1）、布沙卡拉奇胺[（20S）-20-二甲基氨基-2'-羟基-3β-甲基-3'-甲基丁酰氨基-9，10-裂环-布沙-9（11），10（19）-二烯-31-醇]（2）和布沙赫伊胺[（20S）-20-二甲基氨基-2'-羟基-3β-甲基-3'-甲基戊酰氨基-9，10-裂环-布沙-9（11），10（19）-二烯-31-醇]（3）。首次从该物种中分离出四种已知碱，即环原黄杨碱-C（4）、环维罗黄杨星-A（5）、环小叶黄杨碱-A（6）和万年青醇（7）。通过广泛的光谱研究确定了它们的结构。这些化合物大多表现出抗胆碱酯酶活性。