来自欧洲黄杨的新型三萜生物碱。

New triterpenoidal alkaloids from Buxus sempervirens.

作者信息

Ata Athar, Naz Samina, Choudhary M Iqbal, Sener Bilge, Turkoz Songul

机构信息

Department of Chemistry, The University of Winnipeg, Manitoba, Canada.

出版信息

Z Naturforsch C J Biosci. 2002 Jan-Feb;57(1-2):21-8.

PMID:11926538

Abstract

Phytochemical studies on the ethanolic extract of the roots of Buxus sempervirens of Turkish origin have resulted in the isolation of two new triterpenoidal alkaloids, (+)-16a, 31-diacetylbuxadine (1), (-)-Nb-demethylcyclomikuranine (2) along with three known natural products, (-)-cyclomikuranine (3), (-)-cyclobuxophylline-K (4) and (+)-buxaquamarine (5) isolated for the first time from this species of genus Buxus. The structures of these new natural products were established on the basis of extensive spectroscopic studies. Compound 1 exhibited antibacterial activity against human pathogenic bacteria and weak phytotoxic activity against Lemna minor Linn.

摘要

对源自土耳其的常绿黄杨根乙醇提取物进行的植物化学研究，已分离出两种新的三萜生物碱，即(+)-16α, 31-二乙酰黄杨碱(1)、(-)-N_b-去甲基环米库拉宁(2)，以及三种已知天然产物，即首次从该黄杨属植物中分离出的(-)-环米库拉宁(3)、(-)-环黄杨碱-K(4)和(+)-黄杨水胺(5)。这些新天然产物的结构是通过广泛的光谱研究确定的。化合物1对人类病原菌表现出抗菌活性，对浮萍具有较弱的植物毒性活性。