• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Alpha-amanitin resistance: a dominant mutation in CHO cells.

作者信息

Lobban P E, Siminovitch L

出版信息

Cell. 1975 Feb;4(2):167-72. doi: 10.1016/0092-8674(75)90123-3.

DOI:10.1016/0092-8674(75)90123-3
PMID:1168545
Abstract

Hybrids of CHO cells were constructed consisting of either a 1:1 or 1:2 ratio of alpha-amanitin-resistant and sensitive cells, respectively. The resistance of such hybrids to killing by the drug was similar but slightly less than that of the resistant parent. The hybrids contained both resistant and wild-type RNA polymerase II, in amounts related to the expected gene dosage. The alpha-amanitin marker therefore is expressed codominantly.

摘要

相似文献

1
Alpha-amanitin resistance: a dominant mutation in CHO cells.
Cell. 1975 Feb;4(2):167-72. doi: 10.1016/0092-8674(75)90123-3.
2
Regulation of RNA polymerase II activity in alpha-amanitin-resistant CHO hybrid cells.α-鹅膏蕈碱抗性中国仓鼠卵巢杂交细胞中RNA聚合酶II活性的调控
Cell. 1977 Jan;10(1):53-60. doi: 10.1016/0092-8674(77)90139-8.
3
alpha-Amanithin-resistant mutants of Chinese hamster ovary (CHO) cells.
Mutat Res. 1978 Jan;49(1):65-101. doi: 10.1016/0027-5107(78)90081-7.
4
Alpha-Amanitin resistance of RNA polymerase II in mutant Chinese hamster ovary cell lines.
J Biol Chem. 1976 May 10;251(9):2729-34.
5
The RNA polymerase II of an alpha-amanitin-resistant Chinese hamster ovary cell line.一种对α-鹅膏蕈碱耐药的中国仓鼠卵巢细胞系的RNA聚合酶II
Cell. 1976 May;8(1):65-70. doi: 10.1016/0092-8674(76)90186-0.
6
Temperature-sensitive RNA polymerase II mutations in Chinese hamster ovary cells.中国仓鼠卵巢细胞中的温度敏感型RNA聚合酶II突变
Proc Natl Acad Sci U S A. 1978 Jan;75(1):405-9. doi: 10.1073/pnas.75.1.405.
7
Isolation and characterization of an alpha-amanitin-resistant rat myoblast mutant cell line possessing alpha-amanitin-resistant RNA polymerase II.
J Biol Chem. 1975 Jul 10;250(13):4825-31.
8
RNA polymerase B from an alpha-amanitin resistant mouse myeloma cell line.
FEBS Lett. 1976 Oct 15;69(1):6-10. doi: 10.1016/0014-5793(76)80641-2.
9
alpha-Amanitin resistant RNA polymerase II from Aedes albopictus cell mutants resistant to alpha-amanitin.来自对白纹伊蚊α-鹅膏蕈碱有抗性的细胞突变体的α-鹅膏蕈碱抗性RNA聚合酶II
Cell Biol Int Rep. 1979 Dec;3(9):725-32. doi: 10.1016/0309-1651(79)90077-8.
10
Isolation and characterization of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole-resistant mutants of the Chinese hamster ovary cell line.中国仓鼠卵巢细胞系5,6-二氯-1-β-D-呋喃核糖基苯并咪唑抗性突变体的分离与鉴定
Mol Cell Biol. 1982 Apr;2(4):467-77. doi: 10.1128/mcb.2.4.467-477.1982.

引用本文的文献

1
Myogenic differentiation of L6 rat myoblasts: evidence for pleiotropic effects on myogenesis by RNA polymerase II mutations to alpha-amanitin resistance.L6大鼠成肌细胞的肌源性分化：RNA聚合酶II突变为对α-鹅膏蕈碱耐药后对肌生成产生多效性作用的证据。
Mol Cell Biol. 1983 May;3(5):946-55. doi: 10.1128/mcb.3.5.946-955.1983.
2
A method for assaying DNA-dependent RNA polymerase II in crude extracts of Drosophila melanogaster adults: its use in identifying mutants with an altered RNA polymerase II.一种用于测定黑腹果蝇成虫粗提物中DNA依赖性RNA聚合酶II的方法：其在鉴定RNA聚合酶II发生改变的突变体中的应用。
Biochem Genet. 1981 Feb;19(1-2):31-46. doi: 10.1007/BF00486135.
3
Restriction of herpes simplex virus by Ama 1 cells. An analysis of viral macromolecule synthesis.
Ama 1细胞对单纯疱疹病毒的限制。病毒大分子合成分析。
Arch Virol. 1980;64(3):197-211. doi: 10.1007/BF01322700.
4
Localization of an alpha-amanitin resistance mutation in the gene encoding the largest subunit of mouse RNA polymerase II.小鼠RNA聚合酶II最大亚基编码基因中α-鹅膏蕈碱抗性突变的定位
Mol Cell Biol. 1987 Feb;7(2):586-94. doi: 10.1128/mcb.7.2.586-594.1987.
5
Genetic characterization of methotrexate-resistant chinese hamster ovary cells.
In Vitro. 1976 Nov;12(11):749-57. doi: 10.1007/BF02835450.
6
Synthesis of influenza virus polypeptides in cells resistant to alpha-amanitin: evidence for the involvement of cellular RNA polymerase II in virus replication.在对α-鹅膏蕈碱耐药的细胞中流感病毒多肽的合成：细胞RNA聚合酶II参与病毒复制的证据
J Virol. 1977 Sep;23(3):816-9. doi: 10.1128/JVI.23.3.816-819.1977.
7
Temperature-sensitive RNA polymerase II mutations in Chinese hamster ovary cells.中国仓鼠卵巢细胞中的温度敏感型RNA聚合酶II突变
Proc Natl Acad Sci U S A. 1978 Jan;75(1):405-9. doi: 10.1073/pnas.75.1.405.
8
Transfer of codominant markers by isolated metaphase chromosomes in Chinese hamster ovary cells.中国仓鼠卵巢细胞中分离中期染色体对共显性标记的转移
Proc Natl Acad Sci U S A. 1977 Aug;74(8):3480-4. doi: 10.1073/pnas.74.8.3480.