Shapiro B H, Goldman A S
Endocrinology. 1975 Jun;96(6):1392-5. doi: 10.1210/endo-96-6-1392.
The vaginae of about one-third of androgen-insensitive male rat pseudohermaphrodites never open nor can they be opened by the administration of estrogen, progesterone or andorgens. The vaginae of the remaining pseudohermaphrodites open significantly later than normal females, and, once open, require the presence of the testes or exogenous estrogen to maintain their patency. These defects in the vaginal development of the pseudohermaphrodite may be due to some perinatal masculinization of the perineum, unlike most of the phenotypically female development exhibited by this animal.
约三分之一雄激素不敏感型雄性大鼠假两性畸形个体的阴道从未开口，给予雌激素、孕酮或雄激素也无法使其开口。其余假两性畸形个体的阴道开口时间明显晚于正常雌性，而且一旦开口，需要睾丸存在或外源性雌激素来维持通畅。假两性畸形个体阴道发育的这些缺陷可能是由于围产期会阴部的某种男性化，这与该动物表现出的大多数表型为雌性的发育情况不同。
