Rodríguez-Morán M, Guerrero-Romero F
Unidad de Investigación Médica, Hospital General, Instituto Mexicano del Seguro Social (IMSS), Durango, Durango, Mexico.
Arch Med Res. 2000 Jul-Aug;31(4):399-403. doi: 10.1016/s0188-4409(00)00089-8.
This study was undertaken in order to identify the relationships between family history of type 2 diabetes and cardiovascular risk factors in non-diabetic Mexican individuals.
The design was a cross-sectional, population-based study stratified by age and sex. Participants consisted of 189 non-diabetic volunteers 30-64 years of age, both males and non-pregnant females randomly selected from a middle income neighborhood in Durango, Mexico and distributed into two groups, with and without family history of type 2 diabetes mellitus. Hypertensive subjects were excluded. Body mass index (BMI) and waist-to-hip ratio (WHR) were assessed. Hematocrit, both fasting and 2-h post 75-g glucose load insulin, and glucose levels, lipid profile, serum albumin, and proteinuria were measured.
Ninety-four (49.7%) individuals with family history of type 2 diabetes, and 95 (50.3%) in the control group were included. The prevalence of obesity was greater among women with family history of diabetes, 39 (73.6%) vs. 27 (50.0%) of the control group, p = 0.02. Adiposity tended to be centrally distributed in 86 subjects, of whom 22 (25. 6%) males and 54 (62.8%) females were in the group with family history of diabetes and four (4.6%) males and six (7.0%) females in the control group, p <0.000. Multivariate logistic regression analysis showed a strong relationship between family history of type 2 diabetes with both abdominal obesity (odds ratio [OR] 4.2, CI 95% 1.9-10.1, p <0.05) and fasting hyperinsulinemia (OR 3.1, CI 95% 1. 4-11.2, p <0.05).
In the absence of additional risk factors such as diabetes and hypertension, there is a strong relationship between family history of diabetes with hyperinsulinemia and abdominal obesity in middle-aged Mexican individuals.
本研究旨在确定非糖尿病墨西哥人群中2型糖尿病家族史与心血管危险因素之间的关系。
该研究设计为一项基于人群的横断面研究，按年龄和性别分层。参与者包括189名年龄在30 - 64岁之间的非糖尿病志愿者，男女皆有，从墨西哥杜兰戈的一个中等收入社区随机选取，并分为两组，即有和没有2型糖尿病家族史的组。排除高血压患者。评估体重指数（BMI）和腰臀比（WHR）。测量血细胞比容、空腹及75克葡萄糖负荷后2小时的胰岛素和葡萄糖水平、血脂谱、血清白蛋白和蛋白尿。
纳入了94名（49.7%）有2型糖尿病家族史的个体和95名（50.3%）对照组个体。糖尿病家族史女性中的肥胖患病率更高，分别为39名（73.6%）和对照组的27名（50.0%），p = 0.02。86名受试者的肥胖倾向于中心性分布，其中有糖尿病家族史组中有22名（25.6%）男性和54名（62.8%）女性，对照组中有4名（4.6%）男性和6名（7.0%）女性，p <0.000。多因素逻辑回归分析显示2型糖尿病家族史与腹型肥胖（比值比[OR] 4.2，95%可信区间1.9 - 10.1，p <0.05）和空腹高胰岛素血症（OR 3.1，95%可信区间1.4 - 11.2，p <0.05）之间均存在密切关系。
在没有糖尿病和高血压等其他危险因素的情况下，中年墨西哥个体中糖尿病家族史与高胰岛素血症和腹型肥胖之间存在密切关系。
