Takagi M, Akiba T, Yamazaki Y, Nariai K, Iwaki T
Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Surg Today. 2001;31(9):845-7. doi: 10.1007/s005950170063.
The leakage of tracheal anastomoses is one of the major complications that occurs after tracheal reconstruction. Improved reinforcing methods for anastomoses would thus be clinically useful. To find a better technique, we examined the postoperative would-healing effect of fibrin glue on tracheal anastomosis in the rat. Experimental rats were divided into two groups. In the control group (n = 21), the trachea was anastomosed by interrupted absorbable sutures. In the fibrin glue group (n = 21), the trachea was anastomosed in the same manner as the control group, with the addition of fibrin glue around the area of anastomosis. In the two groups, we studied the amount of hydroxyproline and histological findings on the seventh, 14th, and 21st postoperative day. The amount of hydroxyproline and collagen fibers in the fibrin glue group was more than in the control group on the seventh postoperative day. These results suggest that fibrin glue has a promotive effect in the healing of tracheal anastomosis.
气管吻合口漏是气管重建术后发生的主要并发症之一。因此，改进吻合口的加固方法在临床上将很有用。为了找到更好的技术，我们研究了纤维蛋白胶对大鼠气管吻合口术后伤口愈合的影响。实验大鼠分为两组。对照组（n = 21）采用间断可吸收缝线进行气管吻合。纤维蛋白胶组（n = 21）以与对照组相同的方式进行气管吻合，并在吻合区域周围添加纤维蛋白胶。在两组中，我们研究了术后第7天、第14天和第21天的羟脯氨酸含量和组织学结果。术后第7天，纤维蛋白胶组的羟脯氨酸含量和胶原纤维比对照组更多。这些结果表明，纤维蛋白胶对气管吻合口愈合有促进作用。
