Shinohara K, Kobayashi E, Yoshida T, Toyama N, Kiyozaki H, Fujimura A, Miyata M
Department of Surgery, Omiya Medical Center, Jichi Medical School, Tochigi, Japan.
Eur Surg Res. 1998;30(1):8-12. doi: 10.1159/000008552.
Fibrin glue has been used as a hemostatic and adhesive agent for many years, but its efficacy in digestive surgery is still controversial. In this study, we evaluated the effect of fibrin glue on the healing of the small and large bowel anastomotic portions by measurement of the anastomotic bursting pressure. Further, the efficacy of fibrin glue in preventing intra-abdominal adhesion formation was assessed. Our results indicated that fibrin glue enhanced the resistance towards an elevation of intraluminal pressure in small bowel, but not in large bowel. Concomitantly, the glue did not significantly attenuate postoperative adhesion formation. A sealing action of fibrin glue might protect against bleeding and microleakage, resulting in beneficial effects on small bowel anastomosis.
纤维蛋白胶作为一种止血和黏合剂已使用多年，但其在消化外科手术中的疗效仍存在争议。在本研究中，我们通过测量吻合口破裂压力评估了纤维蛋白胶对小肠和大肠吻合部位愈合的影响。此外，还评估了纤维蛋白胶在预防腹腔内粘连形成方面的疗效。我们的结果表明，纤维蛋白胶增强了小肠对管腔内压力升高的抵抗力，但对大肠没有作用。同时，该胶水并未显著减轻术后粘连的形成。纤维蛋白胶的密封作用可能防止出血和微渗漏，从而对小肠吻合术产生有益影响。
