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夏枯草对小鼠模型速发型过敏反应的抑制作用

Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine model.

作者信息

Shin T Y, Kim Y K, Kim H M

机构信息

College of Pharmacy, Woosuk University, Chonju, Chonbuk, South Korea.

出版信息

Immunopharmacol Immunotoxicol. 2001 Aug;23(3):423-35. doi: 10.1081/iph-100107341.

Abstract

We studied the effect of aqueous extract of Prunella vulgaris (Labiatae) (PVAE) on immediate-type allergic reactions. PVAE (0.005 to 1 g/kg) dose-dependently inhibited systemic anaphylactic shock induced by compound 48/ 80 in rats. When PVAE was given as pretreatment, at concentrations ranging from 0.005 to 1 g/kg, the serum histamine levels induced by compound 48/ 80 were reduced in a dose-dependent manner. PVAE (0.001 to 1 g/kg) inhibited the passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE antibody dose dependently. PVAE also inhibited the histamine release induced by compound 48/80 or anti-DNP IgE from the rat peritoneal mast cells (RPMC). The level of cyclic AMP in RPMC, when PVAE was added, significantly increased, compared with that of normal control. Moreover, PVAE (0.01 and 0.1 mg/ml) had a significant inhibitory effect on anti-DNP IgE-mediated tumor necrosis factor-alpha production from RPMC. These results indicate that PVAE inhibits immediate-type allergic reactions in rats.

摘要

我们研究了夏枯草(唇形科)水提取物(PVAE)对速发型过敏反应的影响。PVAE(0.005至1克/千克)剂量依赖性地抑制了化合物48/80诱导的大鼠全身性过敏休克。当PVAE作为预处理给药时,浓度范围为0.005至1克/千克,化合物48/80诱导的血清组胺水平呈剂量依赖性降低。PVAE(0.001至1克/千克)剂量依赖性地抑制了抗二硝基苯基(DNP)IgE抗体激活的被动皮肤过敏反应。PVAE还抑制了化合物48/80或抗DNP IgE从大鼠腹膜肥大细胞(RPMC)诱导的组胺释放。与正常对照相比,添加PVAE时,RPMC中的环磷酸腺苷水平显著增加。此外,PVAE(0.01和0.1毫克/毫升)对RPMC中抗DNP IgE介导的肿瘤坏死因子-α产生具有显著的抑制作用。这些结果表明PVAE抑制大鼠的速发型过敏反应。

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