Achkar J P, Shen B
Department of Gastroenterology, The Cleveland Clinic Foundation, A30, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Curr Gastroenterol Rep. 2001 Dec;3(6):484-90. doi: 10.1007/s11894-001-0069-5.
Surgical intervention is often required for patients with inflammatory bowel disease. Total proctocolectomy with ileal pouch-anal anastomosis is the surgical treatment of choice for patients with ulcerative colitis. The main long-term complication of this surgery is pouchitis, with 10-year cumulative incidence rates between 24% and 46%. For patients with Crohn's disease, postoperative recurrence is a significant problem, with clinical recurrence rates as high as 55% at 5 years and 76% at 15 years. Increasing evidence suggests that postoperative medical therapy has the potential to decrease the risk of postoperative Crohn's disease recurrence.
炎症性肠病患者通常需要手术干预。全直肠结肠切除术加回肠储袋肛管吻合术是溃疡性结肠炎患者的首选手术治疗方法。该手术的主要长期并发症是储袋炎，10年累积发病率在24%至46%之间。对于克罗恩病患者，术后复发是一个重大问题，临床复发率在5年时高达55%，在15年时高达76%。越来越多的证据表明，术后药物治疗有可能降低克罗恩病术后复发的风险。
