[海洋生物聚糖的比较免疫活性]

[Comparative immunologic activity of marine bioglycans].

作者信息

Zaporozhets T S, Besednova N N, Molchanova V N, Zviagintseva T N

机构信息

Research Institute of Epidemiology and Microbiology, Siberian Branch of the Russian Academy of Medical Sciences, Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok.

出版信息

Antibiot Khimioter. 2001;46(7):6-10.

PMID:11697245

Abstract

Immunomodulating activity of three marine bioglycanes of different structure was investigated. The following preparations were compared: mitilan--glycoprotein, containing 1,4-alpha-D-glucane, isolated from mussel Crenomytilus grayanus; translam--beta-1,3; 1,6-beta-D-glucane isolated from Laminaria cichorioides and zosterin--low-metoxylated pectine isolated from marine plant of genera Zosteraceae. It was shown that immune response modulating was due to delicate and complex interaction of immune competent cells with cytokins participation. All bioglycanes investigated when introduced into animals organism produced changes in immune system: spleen mass enlarged, lymphocytes subpopulation redistributed, nonspecific T-supressors activity enhanced, content of interferone in blood serum increased. It is considered that similarity of immune system reactions is due to polysaccharide component of investigated biopolymers and potency of the effect is determined by structural specificity and by stereochemistry of each bioglycane.

摘要

研究了三种不同结构的海洋生物聚糖的免疫调节活性。对以下制剂进行了比较：米替兰——从贻贝Crenomytilus grayanus中分离出的含有1,4-α-D-葡聚糖的糖蛋白；translam——从菊苣海带Laminaria cichorioides中分离出的β-1,3；1,6-β-D-葡聚糖以及带状菌素——从带状藻科海洋植物中分离出的低甲氧基化果胶。结果表明，免疫反应调节是由于免疫活性细胞在细胞因子参与下的微妙而复杂的相互作用。所有研究的生物聚糖引入动物机体后都会引起免疫系统的变化：脾脏肿大，淋巴细胞亚群重新分布，非特异性T抑制细胞活性增强，血清中干扰素含量增加。据认为，免疫系统反应的相似性归因于所研究生物聚合物的多糖成分，而效应的强度则由每种生物聚糖的结构特异性和立体化学决定。