Henry C J, McCaw D L, Brock K V, Stoker A M, Tyler J W, Tate D J, Higginbotham M L
Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA.
J Am Vet Med Assoc. 2001 Nov 1;219(9):1238-41. doi: 10.2460/javma.2001.219.1238.
To determine the association between cancer chemotherapy and serum canine distemper virus (CDV), canine parvovirus (CPV), and rabies virus antibody titers in tumor-bearing dogs.
Prospective study.
21 client-owned dogs with various malignancies and 16 client-owned dogs with lymphoma.
In study A, serum antibody titers were measured by use of hemagglutination inhibition (CPV titers) or serum neutralization (CDV titers) before and at least 1 month after initiation of chemotherapy. Baseline values were compared with values obtained from a control population of 122 healthy dogs seen for routine revaccination. Titers were considered protective at > or = 1:96 for CDV and > or = 1:80 for CPV. In study B, serum IgG titers were measured by use of immunofluorescent assay (CDV and CPV titers) and rapid fluorescent focus inhibition test (RFFIT, rabies titers) at baseline and again at weeks 5, 8, and 24 of a standard chemotherapy protocol for treatment of lymphoma. An IgG titer of > or = 1:50 was considered protective for CPV and CDV. An RFFIT titer of > or = 0.5 U/ml was considered protective for rabies virus.
Significant changes were not detected in CDV, CPV, and rabies virus titers following chemotherapy in tumor-bearing dogs.
Results suggest that established immunity to CDV, CPV, and rabies virus from previous vaccination is not significantly compromised by standard chemotherapy used to treat tumor-bearing dogs.
确定患肿瘤犬的癌症化疗与血清犬瘟热病毒（CDV）、犬细小病毒（CPV）及狂犬病病毒抗体滴度之间的关联。
前瞻性研究。
21只客户拥有的患有各种恶性肿瘤的犬以及16只客户拥有的患有淋巴瘤的犬。
在研究A中，在化疗开始前及开始后至少1个月，采用血凝抑制法（检测CPV滴度）或血清中和法（检测CDV滴度）测量血清抗体滴度。将基线值与从122只接受常规再接种疫苗的健康犬组成的对照群体中获得的值进行比较。CDV滴度≥1:96、CPV滴度≥1:80时被认为具有保护性。在研究B中，在治疗淋巴瘤的标准化疗方案的基线期以及第5、8和24周，采用免疫荧光法（检测CDV和CPV滴度）和快速荧光灶抑制试验（RFFIT，检测狂犬病滴度）测量血清IgG滴度。CPV和CDV的IgG滴度≥1:50被认为具有保护性。狂犬病病毒的RFFIT滴度≥0.5 U/ml被认为具有保护性。
患肿瘤犬化疗后，CDV、CPV和狂犬病病毒滴度未检测到显著变化。
结果表明，用于治疗患肿瘤犬的标准化疗不会显著损害先前接种疫苗所建立的对CDV、CPV和狂犬病病毒的免疫力。
