Lee I S, Shin Y K, Chung D H, Park S H
Department of Pathology, Seoul National University College of Medicine, Korea.
Leuk Lymphoma. 2001 Aug;42(4):587-94. doi: 10.3109/10428190109099318.
Hodgkin's and Reed-Sternberg (H-RS) cells are morphological hallmarks of Hodgkin's disease (HD). So far, several characteristics frequently seen in H-RS cells from different origins have been described, such as the high expression of Epstein-Barr virus latent membrane protein 1 (LMP1), the elevation of NF-kappaB activity, and the aberrant expression of molecules such as CD15, CD30, and CD99. Despite extensive studies on the nature of H-RS cells, the molecular mechanism by which H-RS cells are generated remained elusive. Recently, the forced down-regulation of CD99 was reported to induce typical H-RS phenotypes in vitro in a B cell line. Furthermore, it was revealed that LMP1 markedly reduces the CD99 expression at the transcriptional level. Since the presence of LMP1 is known to be associated with the H-RS cell formation, the data provide a possibility of linkage between LMP1 and HD via CD99, thus suggesting that, at least in part, the loss of CD99 may play a critical role in the pathogenic sequence to the formation of H-RS cells in HD. In this review, the role of CD99 in the generation of H-RS cells and its molecular mechanism will be suggested.
霍奇金和里德-施特恩伯格（H-RS）细胞是霍奇金淋巴瘤（HD）的形态学标志。到目前为止，已经描述了来自不同来源的H-RS细胞中常见的几个特征，例如EB病毒潜伏膜蛋白1（LMP1）的高表达、NF-κB活性的升高以及CD15、CD30和CD99等分子的异常表达。尽管对H-RS细胞的本质进行了广泛研究，但H-RS细胞产生的分子机制仍然不清楚。最近，据报道在体外B细胞系中强制下调CD99可诱导典型的H-RS表型。此外，还发现LMP1在转录水平上显著降低CD99的表达。由于已知LMP1的存在与H-RS细胞形成有关，这些数据提供了通过CD99将LMP1与HD联系起来的可能性，因此表明至少在部分情况下，CD99的缺失可能在HD中H-RS细胞形成的致病过程中起关键作用。在这篇综述中，将阐述CD99在H-RS细胞产生中的作用及其分子机制。
