Yoo Seong-Ho, Han Jungho, Kim Tae Jin, Chung Doo Hyun
Department of Pathology, Seoul National University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2005 Feb;20(1):50-5. doi: 10.3346/jkms.2005.20.1.50.
Pleomorphic carcinoma of the lung (PCL) is characterized by a mixture of sarcomatoid and carcinoma components, and a poor prognosis. However, no immunophenotype of tumor markers has been characterized in PCL. To characterize the immunophenotype for CD99 in PCL, we performed an immunohistochemical evaluation of PCLs for thyroid transcription factor-1 (TTF-1), cytokeratin (CK) 7 and 20, and for CD99. CD99 was found to be expressed in both carcinomatous (47%) and sarcomatous components such as spindle cells (92%) and giant cells (57%). In the case of spindle cells, CK7 was expressed in 6 cases (46%) and TTF-1 in 2 cases (15%), whereas for giant cells CK7 was expressed in 8 cases (57%) and TTF-1 in one case (7%). However, CK20 was not expressed in either the carcinomatous or sarcomatous components in any case. Thus, CD99 was found to be widely expressed in both sarcomatous and carcinoma component in PCL. A clinicopathological analysis showed no direct correlation between the expression of CD99 and the clinical indices (stage, survival rate, invasion) of PCL.
肺多形性癌（PCL）的特征是肉瘤样和癌成分混合，预后较差。然而，PCL中尚未对肿瘤标志物的免疫表型进行特征描述。为了明确PCL中CD99的免疫表型，我们对PCL进行了甲状腺转录因子-1（TTF-1）、细胞角蛋白（CK）7和20以及CD99的免疫组化评估。发现CD99在癌性成分（47%）以及肉瘤样成分如梭形细胞（92%）和巨细胞（57%）中均有表达。在梭形细胞中，6例（46%）表达CK7，2例（15%）表达TTF-1；而对于巨细胞，8例（57%）表达CK7，1例（7%）表达TTF-1。然而，在任何情况下，癌性或肉瘤样成分中均未表达CK20。因此，发现CD99在PCL的肉瘤样和癌性成分中均广泛表达。临床病理分析显示，CD99的表达与PCL的临床指标（分期、生存率、侵袭）之间无直接相关性。
