复制时间延迟会导致有丝分裂染色体凝聚延迟以及染色体易位的染色体不稳定性。
Delayed replication timing leads to delayed mitotic chromosome condensation and chromosomal instability of chromosome translocations.
作者信息
Smith L, Plug A, Thayer M
机构信息
Division of Molecular Medicine, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, Portland, OR 97201, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13300-5. doi: 10.1073/pnas.241355098.
Abstract
Chromosomal rearrangements are found in virtually all types of human cancers. We show that certain chromosome translocations display a delay in mitotic chromosome condensation that is associated with a delay in the mitosis-specific phosphorylation of histone H3. This delay in mitotic condensation is preceded by a delay in both the initiation as well as the completion of chromosome replication. In addition, chromosomes with this phenotype participate in numerous secondary translocations and rearrangements. Chromosomes with this phenotype were detected in five of seven tumor-derived cell lines and in five of thirteen primary tumor samples. These data suggest that certain chromosomal rearrangements found in tumor cells cause a significant delay in replication timing of the entire chromosome that subsequently results in delayed mitotic chromosome condensation and ultimately in chromosomal instability.
摘要
几乎在所有类型的人类癌症中都能发现染色体重排。我们发现，某些染色体易位会导致有丝分裂染色体凝聚延迟，这与组蛋白H3的有丝分裂特异性磷酸化延迟有关。这种有丝分裂凝聚延迟之前，染色体复制的起始和完成都会延迟。此外，具有这种表型的染色体还会参与大量的二次易位和重排。在7个肿瘤衍生细胞系中的5个以及13个原发性肿瘤样本中的5个中检测到了具有这种表型的染色体。这些数据表明，肿瘤细胞中发现的某些染色体重排会导致整个染色体的复制时间显著延迟，随后导致有丝分裂染色体凝聚延迟，最终导致染色体不稳定。
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