Csink A K, Henikoff S
Fred Hutchinson, Cancer Research Center, Seattle, WA 98109-1024, USA.
Trends Genet. 1998 May;14(5):200-4. doi: 10.1016/s0168-9525(98)01444-9.
Large blocks of tandemly repeated sequences, or satellites, surround the centromeres of complex eukaryotes. During mitosis in Drosophila, satellite DNA binds proteins that, during interphase, bind other sites. The requirement for a repeat to borrow a partner protein from those available at mitosis might limit the spectrum of repeat units that can be expanded into large blocks. To account for the ubiquity and pericentric localization of satellites, we propose that they are utilized to maintain regions of late replication, thus ensuring that the centromere is the last region to replicate on a chromosome.
大量串联重复序列，即卫星序列，环绕着复杂真核生物的着丝粒。在果蝇有丝分裂期间，卫星DNA结合蛋白质，这些蛋白质在间期会结合其他位点。一个重复序列需要从有丝分裂时可用的蛋白质中借用伙伴蛋白质，这可能会限制能够扩展成大块的重复单元的范围。为了解释卫星序列的普遍性和着丝粒周围定位，我们提出它们被用于维持晚复制区域，从而确保着丝粒是染色体上最后一个复制的区域。
