Kobayashi T, Yamamoto K, Sugita N, van der Pol W L, Yasuda K, Kaneko S, van de Winkel J G, Yoshie H
Division of Periodontology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
J Periodontol. 2001 Oct;72(10):1324-31. doi: 10.1902/jop.2001.72.10.1324.
Functional polymorphisms of immunoglobulin G (IgG) Fc receptors (Fc gamma R) have been shown to be associated with generalized aggressive periodontitis (GAgP) or recurrence of chronic periodontitis (CP) in Japanese patients. The purpose of this study was to evaluate whether Fc gamma R polymorphisms are also associated with severity of CP.
Fifty Japanese non-smoking patients with severe CP and 39 Japanese non-smoking patients with moderate CP were identified according to established clinical criteria, including measurements of probing depth (PD), clinical attachment level (CAL), and alveolar bone loss (BL). Fc gamma R genotypes for 3 bi-allelic polymorphisms (Fc gamma RIIa-R/H131, Fc gamma RIIIa-158V/F, Fc gamma RIIIb-NA1/NA2) were determined in these CP patients and 64 race-matched, non-smoking healthy controls by means of allele-specific polymerase chain reactions.
There was a significant over-representation of Fc gamma RIIIa-158V allele in severe CP patients compared to moderate CP patients (odds ratio 2.03, 95% confidence interval [CI] 1.03-4.01, chi 2 = 4.86, P = 0.028). In addition, we found a strong association between CP severity and Fc gamma R composite genotype comprising Fc gamma RIIIa-158V plus Fc gamma RIIIb-NA2 (severe CP versus moderate CP: odds ratio 4.69, 95% CI 1.52-15.10, chi 2 = 9.35, P = 0.002; severe CP versus healthy controls: odds ratio 4.10, 95% CI 1.62-10.59, chi 2 = 11.13, P = 0.0009). Moreover, CP patients positive for the composite genotype exhibited more severe signs of periodontitis than composite genotype-negative individuals (positive versus negative; mean PD: 3.8 mm versus 3.2 mm, P = 0.005; mean CAL: 4.5 mm versus 3.7 mm, P = 0.005; mean % BL: 37.6% versus 29.9%, P = 0.008).
Our results document the Fc gamma RIIIa-158V allele and possibly Fc gamma RIIIb-NA2 to be associated with severity of CP in Japanese patients.
免疫球蛋白G（IgG）Fc受体（FcγR）的功能多态性已被证明与日本患者的广泛侵袭性牙周炎（GAgP）或慢性牙周炎（CP）复发有关。本研究的目的是评估FcγR多态性是否也与CP的严重程度相关。
根据既定的临床标准，包括探诊深度（PD）、临床附着水平（CAL）和牙槽骨丧失（BL）的测量，确定了50名患有重度CP的日本非吸烟患者和39名患有中度CP的日本非吸烟患者。通过等位基因特异性聚合酶链反应，在这些CP患者和64名种族匹配的非吸烟健康对照中确定了3种双等位基因多态性（FcγRIIa-R/H131、FcγRIIIa-158V/F、FcγRIIIb-NA1/NA2）的FcγR基因型。
与中度CP患者相比，重度CP患者中FcγRIIIa-158V等位基因的比例显著过高（优势比2.03，95%置信区间[CI]1.03 - 4.01，χ2 = 4.86，P = 0.028）。此外，我们发现CP严重程度与包含FcγRIIIa-158V加FcγRIIIb-NA2的FcγR复合基因型之间存在强关联（重度CP与中度CP：优势比4.69，95%CI 1.52 - 15.10，χ2 = 9.35，P = 0.002；重度CP与健康对照：优势比4.10，95%CI 1.62 - 10.59，χ2 = 11.13，P = 0.0009）。此外，复合基因型阳性的CP患者比复合基因型阴性的个体表现出更严重的牙周炎症状（阳性与阴性；平均PD：3.8 mm对3.2 mm，P = 0.005；平均CAL：4.5 mm对3.7 mm，P = 0.005；平均%BL：37.6%对29.9%，P = 0.008）。
我们的结果证明FcγRIIIa-158V等位基因以及可能的FcγRIIIb-NA2与日本患者CP的严重程度相关。
