Laine Marja L, Loos Bruno G, Crielaard W
Department of Oral Microbiology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije University, 1081 BT Amsterdam, The Netherlands.
Int J Dent. 2010;2010:324719. doi: 10.1155/2010/324719. Epub 2010 Feb 9.
We aimed to conduct a review of the literature for gene polymorphisms associated with chronic periodontitis (CP) susceptibility. A comprehensive search of the literature in English was performed using the keywords: periodontitis, periodontal disease, combined with the words genes, mutation, or polymorphism. Candidate gene polymorphism studies with a case-control design and reported genotype frequencies in CP patients were searched and reviewed. There is growing evidence that polymorphisms in the IL1, IL6, IL10, vitamin D receptor, and CD14 genes may be associated with CP in certain populations. However, carriage rates of the rare (R)-allele of any polymorphism varied considerably among studies and most of the studies appeared under-powered and did not correct for other risk factors. Larger cohorts, well-defined phenotypes, control for other risk factors, and analysis of multiple genes and polymorphisms within the same pathway are needed to get a more comprehensive insight into the contribution of gene polymorphisms in CP.
我们旨在对与慢性牙周炎（CP）易感性相关的基因多态性进行文献综述。使用关键词“牙周炎”“牙周疾病”并结合“基因”“突变”或“多态性”等词汇，对英文文献进行了全面检索。检索并综述了采用病例对照设计且报告了CP患者基因型频率的候选基因多态性研究。越来越多的证据表明，白细胞介素1（IL1）、白细胞介素6（IL6）、白细胞介素10（IL10）、维生素D受体和CD14基因的多态性在某些人群中可能与CP相关。然而，各研究中任何多态性的罕见（R）等位基因携带率差异很大，且大多数研究样本量似乎不足，未对其他风险因素进行校正。需要更大的队列、明确的表型、对其他风险因素的控制以及对同一途径内多个基因和多态性的分析，以便更全面地了解基因多态性在CP中的作用。
