哮喘患者症状与气道阻塞客观指标之间的关系。

Relationship between symptoms and objective measures of airway obstruction in asthmatic patients.

作者信息

Liam C K, Goh C T, Isahak M, Lim K H, Wong C M

机构信息

Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

出版信息

Asian Pac J Allergy Immunol. 2001 Jun;19(2):79-83.

PMID:11699724

Abstract

The objective of this study was to determine the relationship between asthma symptoms and the degree of airway obstruction as measured by the forced expiratory volume in one second (FEV1) and peak expiratory flow rate (PEFR) in a group of 64 asthmatic patients with clinically stable disease attending a university-based urban asthma clinic. Asthma symptoms did not correlate with the degree of airway obstruction as measured by prebronchodilator PEFR (total asthma symptom score vs PEFR: r = -0.214, p = 0.104, n = 59) and only correlated poorly with prebronchodilator FEV1 (total asthma symptom score vs FEV1: r = -0.256, p = 0.041, n = 64). These results lend support to the recommendation that airway obstruction should be measured objectively when assessing patients with chronic persistent asthma.

摘要

本研究的目的是确定在一所大学城市哮喘诊所就诊的64例临床病情稳定的哮喘患者中，哮喘症状与通过一秒用力呼气量（FEV1）和呼气峰值流速（PEFR）所测量的气道阻塞程度之间的关系。哮喘症状与支气管扩张剂使用前PEFR所测量的气道阻塞程度不相关（总哮喘症状评分与PEFR：r = -0.214，p = 0.104，n = 59），且与支气管扩张剂使用前FEV1仅存在弱相关性（总哮喘症状评分与FEV1：r = -0.256，p = 0.041，n = 64）。这些结果支持了在评估慢性持续性哮喘患者时应客观测量气道阻塞的建议。