Maguire-Zeiss K A, Bowers W J, Federoff H J
Department of Neurology, University of Rochester School of Medicine and Dentistry, NY 14642, USA.
Curr Opin Mol Ther. 2001 Oct;3(5):482-90.
The efficient and targeted transfer of genes is the goal of gene therapy. In the central nervous system (CNS), this is challenging due in part to the exquisite anatomy of the brain. Herpes simplex virus (HSV) vectors are particularly amenable to CNS therapies as they are capable of transducing a variety of cells, have a large transgene capacity and can exist as either oncolytic or non-immunogenic vectors. The versatility of this vector platform and its potential molecular therapeutic use in two CNS disorders, Alzheimer's disease and malignant brain tumors, will be discussed.
基因的高效靶向转移是基因治疗的目标。在中枢神经系统（CNS）中，这颇具挑战性，部分原因在于大脑精细的解剖结构。单纯疱疹病毒（HSV）载体特别适用于中枢神经系统治疗，因为它们能够转导多种细胞，具有较大的转基因容量，并且可以作为溶瘤或非免疫原性载体存在。本文将讨论该载体平台的多功能性及其在两种中枢神经系统疾病——阿尔茨海默病和恶性脑肿瘤中的潜在分子治疗用途。
