Köles L, Wirkner K, Illes P
Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Germany.
Neurochem Res. 2001 Sep;26(8-9):925-32. doi: 10.1023/a:1012380416876.
Glutamate is the major excitatory neurotransmitter in the brain. It acts at ligand-gated cationic channels (NMDA, AMPA and kainate receptors) and at G protein-coupled metabotropic glutamate receptors as well. The glutamatergic transmission is suggested to be involved in development, learning and memory. Its dysfunction can be detected in epilepsy, stroke, neurodegenerative disorders and drug abuse. This paper summarizes the present knowledge on the modulation of glutamate-gated ion channels in the central nervous system by phosphorylation. An inhibitory interaction between adenosine A2A receptors and NMDA receptors in the neostriatum is described as an example. mediated by the phospholipase C/inositol trisphosphate/calmodulin and calmodulin kinase II pathway.
谷氨酸是大脑中的主要兴奋性神经递质。它作用于配体门控阳离子通道（NMDA、AMPA和海人酸受体）以及G蛋白偶联的代谢型谷氨酸受体。谷氨酸能传递被认为与发育、学习和记忆有关。其功能障碍可在癫痫、中风、神经退行性疾病和药物滥用中检测到。本文总结了目前关于磷酸化对中枢神经系统中谷氨酸门控离子通道调节的认识。以新纹状体中腺苷A2A受体与NMDA受体之间的抑制性相互作用为例进行了描述，该相互作用由磷脂酶C/肌醇三磷酸/钙调蛋白和钙调蛋白激酶II途径介导。
