解码生命的新方法：系统生物学。

A new approach to decoding life: systems biology.

作者信息

Ideker T, Galitski T, Hood L

机构信息

Institute for Systems Biology, Seattle, Washington 98105, USA.

出版信息

Annu Rev Genomics Hum Genet. 2001;2:343-72. doi: 10.1146/annurev.genom.2.1.343.

DOI:10.1146/annurev.genom.2.1.343

PMID:11701654

Abstract

Systems biology studies biological systems by systematically perturbing them (biologically, genetically, or chemically); monitoring the gene, protein, and informational pathway responses; integrating these data; and ultimately, formulating mathematical models that describe the structure of the system and its response to individual perturbations. The emergence of systems biology is described, as are several examples of specific systems approaches.

摘要

系统生物学通过对生物系统进行系统性扰动（生物学、遗传学或化学方法）来研究这些系统；监测基因、蛋白质和信息通路的反应；整合这些数据；并最终构建描述系统结构及其对个体扰动反应的数学模型。本文介绍了系统生物学的兴起，以及一些具体系统方法的实例。