Kumar Pankaj, Kumar Vinay, Sharma Shagun, Sharma Rohit, Warghat Ashish R
Department of Biotechnology, Dr Y.S, Parmar University of Horticulture and Forestry, Solan, Himachal Pradesh, India.
Department of Forest Products, Dr Y.S, Parmar University of Horticulture and Forestry, Solan, Himachal Pradesh, India.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar;398(3):2209-2228. doi: 10.1007/s00210-024-03502-z. Epub 2024 Oct 9.
Medicinal Fritillaria herbs, known for their rich content of steroidal alkaloids, have emerged as promising candidates in the treatment of chronic diseases due to their diverse pharmacological properties. Leveraging advancements in network pharmacology and molecular docking, this study explores the multi-target mechanisms through which these alkaloids exert therapeutic effects. The integration of bioinformatics, systems biology, and pharmacology in drug discovery has provided insights into the molecular interactions and pathways influenced by Fritillaria steroidal alkaloids. This review synthesizes comprehensive literature from 1985 to 2024, revealing the potential of these compounds in addressing respiratory diseases, inflammation, and cancer. The integration of traditional Chinese medicine (TCM) with modern pharmacological techniques underscores the relevance of these compounds in next-generation drug discovery. While initial findings are promising, further empirical validation is necessary to fully harness the therapeutic potential of Fritillaria steroidal alkaloids.
川贝母类药材以其丰富的甾体生物碱含量而闻名，由于其多样的药理特性，已成为治疗慢性疾病的有前景的候选药物。本研究利用网络药理学和分子对接技术的进展，探索这些生物碱发挥治疗作用的多靶点机制。生物信息学、系统生物学和药理学在药物发现中的整合，为川贝母甾体生物碱影响的分子相互作用和途径提供了见解。这篇综述综合了1985年至2024年的全面文献，揭示了这些化合物在治疗呼吸系统疾病、炎症和癌症方面的潜力。中药与现代药理学技术的整合强调了这些化合物在下一代药物发现中的相关性。虽然初步研究结果很有前景，但需要进一步的实证验证，以充分发挥川贝母甾体生物碱的治疗潜力。
