多种物质滥用易感性基因：使用1004名受试者和1494个单核苷酸多态性进行关联的基因组扫描。
Polysubstance abuse-vulnerability genes: genome scans for association, using 1,004 subjects and 1,494 single-nucleotide polymorphisms.
作者信息
Uhl G R, Liu Q R, Walther D, Hess J, Naiman D
机构信息
Molecular Neurobiology Branch, National Institute of Drug Abuse, National Institutes of Health, Baltimore, MD, USA.
出版信息
Am J Hum Genet. 2001 Dec;69(6):1290-300. doi: 10.1086/324467. Epub 2001 Nov 6.
Abstract
Strong genetic contributions to drug abuse vulnerability are well documented, but few chromosomal locations for human drug-abuse vulnerability alleles have been confirmed. We now identify chromosomal markers whose alleles distinguish drug abusers from control individuals in each of two samples, on the basis of pooled-sample microarray and association analyses. Reproducibly positive chromosomal regions defined by these markers in conjunction with previous results were especially unlikely to have been identified by chance. Positive markers identify the alcohol dehydrogenase (ADH) locus, flank the brain-derived neurotropic factor (BDNF) locus, and mark seven other regions previously linked to vulnerability to nicotine or alcohol abuse. These data support polygenic contributions of common allelic variants to polysubstance abuse vulnerability.
摘要
药物滥用易感性存在强大的遗传因素，这一点已有充分记录，但已确认的人类药物滥用易感性等位基因的染色体位置却很少。我们现在基于混合样本微阵列和关联分析，在两个样本中分别识别出其等位基因可区分药物滥用者与对照个体的染色体标记。这些标记所定义的可重复出现的阳性染色体区域，结合先前的结果，极不可能是偶然发现的。阳性标记识别出乙醇脱氢酶（ADH）基因座，位于脑源性神经营养因子（BDNF）基因座两侧，并标记出其他七个先前与尼古丁或酒精滥用易感性相关的区域。这些数据支持常见等位基因变异对多种物质滥用易感性的多基因贡献。
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