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Genetic of addiction: common and uncommon factors.成瘾的遗传学：常见与罕见因素
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Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse.血清素转运体和受体基因的多态性：物质滥用易感性
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多药滥用者中单胺氧化酶B可变数目串联重复多态性与可卡因和阿片类药物成瘾之间的关联

The Association between a MAOB Variable Number Tandem Repeat Polymorphism and Cocaine and Opiate Addictions in Polyconsumers.

作者信息

Mateu César, Rodríguez-Arias Marta, Gil-Miravet Isis, Benito Ana, Tomás José M, Haro Gonzalo

机构信息

Unidad Salud Mental Burjassot, Hospital Arnau de Vilanova-Lliria, 46015 Valencia, Spain.

Grupo de Investigación TXP, Departamento de Medicina, Cardenal Herrera University (CEU), 12006 Castellón de la Plana, Spain.

出版信息

Brain Sci. 2021 Sep 24;11(10):1265. doi: 10.3390/brainsci11101265.

DOI:10.3390/brainsci11101265
PMID:34679329
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8534042/
Abstract

Genetic analysis of the association between alcohol, cocaine, and opiate addiction and variable number tandem repeat (VNTR) polymorphisms in monoamine oxidase B (MAOB) and serotonergic 5-hydroxytryptamine (serotonin) receptor 1B and 2C (HTR1B 21 and HTR2C) pathway genes was performed in a sample of 302 polyconsumers. Our genetic association analysis revealed a significant association between a 184 base pair (bp) VNTR polymorphism in the MAOB gene and addiction to cocaine and opiates. This work highlights new genetic marker associations in cocaine and opiate polyconsumer addictions. These data help to clarify and quantify the complex role of genetics in addictive disorders, as well as their future contribution to the prevention (genetic counselling), diagnosis (genetic diagnosis of vulnerability), and treatment (pharmacogenomics) of these disorders.

摘要

对302名多种药物滥用者样本进行了酒精、可卡因和阿片类成瘾与单胺氧化酶B（MAOB）以及血清素能5-羟色胺（血清素）受体1B和2C（HTR1B 21和HTR2C）途径基因中的可变数目串联重复（VNTR）多态性之间关联的基因分析。我们的基因关联分析揭示了MAOB基因中一个184碱基对（bp）的VNTR多态性与可卡因和阿片类成瘾之间存在显著关联。这项研究突出了可卡因和阿片类多种药物滥用成瘾中新的基因标记关联。这些数据有助于阐明和量化遗传学在成瘾性疾病中的复杂作用，以及它们未来对这些疾病的预防（遗传咨询）、诊断（易感性的基因诊断）和治疗（药物基因组学）的贡献。