Carbonell P, Coll J
Institut d'Investigacions Químiques i Ambientals de Barcelona Josep Pascual Vila, CSIC, Barcelona 08034, Spain.
Phytochem Anal. 2001 Jan-Feb;12(1):73-8. doi: 10.1002/1099-1565(200101/02)12:1<73::AID-PCA561>3.0.CO;2-8.
New neo-clerodane diterpenes have been isolated from Ajuga reptans, and named ajugatansins, along with the previously reported ajugavensin A and ajugareptansone A. The structures of all the compounds were elucidated by spectroscopic means and comparison with closely related compounds reported in the literature. The new 6 alpha,19-diacetoxy-4 alpha,18-epoxy-1 beta-hydroxy-3 beta-(2-methyl-butanoyloxy)-neo-clerod-13-en-15,16-olide (ajugatansin A1) and 6 alpha,19-diacetoxy-4 alpha,18-epoxy-3 beta-hydroxy-12S-(2-methylbutanoyloxy)-neo-clerod-13-en-15,16-olide (ajugatansin B1) are structurally related to ajugarin I and (11S,13R,16S)-6 alpha, 19-diacetoxy-4 alpha,18:11,16:15,16-triepoxy-3 beta-(2-methylbutanoyloxy)-1 beta-[(E)-2-methyl-2-butenoyloxy]-neo-clerodan-2 beta-ol (ajugatansin D1) to dihydroclerodin.
从匍匐筋骨草中分离出了新的新克罗烷二萜，并将其命名为筋骨草素，同时还有之前报道的筋骨草文素A和筋骨草酮A。所有化合物的结构均通过光谱手段并与文献中报道的密切相关化合物进行比较得以阐明。新的6α,19 - 二乙酰氧基 - 4α,18 - 环氧 - 1β - 羟基 - 3β - (2 - 甲基 - 丁酰氧基) - 新克罗 - 13 - 烯 - 15,16 - 内酯（筋骨草素A1）和6α,19 - 二乙酰氧基 - 4α,18 - 环氧 - 3β - 羟基 - 12S - (2 - 甲基丁酰氧基) - 新克罗 - 13 - 烯 - 15,16 - 内酯（筋骨草素B1）在结构上与筋骨草苷I相关，而(11S,13R,16S) - 6α,19 - 二乙酰氧基 - 4α,18:11,16:15,16 - 三环氧 - 3β - (2 - 甲基丁酰氧基) - 1β - [(E) - 2 - 甲基 - 2 - 丁烯酰氧基] - 新克罗丹 - 2β - 醇（筋骨草素D1）与二氢筋骨草素相关。
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