[黄芩属植物成分的研究。十五。高山黄芩叶中的二萜类成分]

[Studies on the constituents of Scutellaria species. XV. On the diterpenoid constituents of the leaves of Scutellaria alpina L].

作者信息

Miyaichi Y, Kizu H, Yamaguchi Y, Tomimori T

机构信息

Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.

出版信息

Yakugaku Zasshi. 1994 Apr;114(4):264-71. doi: 10.1248/yakushi1947.114.4_264.

DOI:10.1248/yakushi1947.114.4_264

PMID:8201548

Abstract

From the leaves of Scutellaria alpina L., four new neo-clerodane diterpenes (1-4) were isolated. The structures of 1-4 were shown to be (4S)-19-acetoxy-8 beta-hydroxy-6 alpha-benzoyloxy-4,18-epoxy-neo-cleroda-11,13- dien-15,16-olide, (4S)-19-acetoxy-8 beta-hydroxy-6 alpha-tigloyloxy-4,18-epoxy-neo-cleroda-11,13- dien-15,16-olide, (4S, 11S)-11-acetoxy-8 beta,19-dihydroxy-6 alpha-tigloyloxy-4,18-epoxy-neo- clerod-13-en-15,16-olide, and (4S)-19-acetoxy-8 beta-hydroxy-6 alpha, 7 beta-dibenzoyloxy-4,18-epoxy-neo- cleroda-11,13-dien-15,16-olide, respectively, by the chemical and spectral data.

摘要

从高山黄芩（Scutellaria alpina L.）的叶子中分离出了四种新的新克罗烷二萜（1-4）。通过化学和光谱数据表明，1-4的结构分别为（4S）-19-乙酰氧基-8β-羟基-6α-苯甲酰氧基-4,18-环氧-新克罗达-11,13-二烯-15,16-内酯、（4S）-19-乙酰氧基-8β-羟基-6α-惕各酰氧基-4,18-环氧-新克罗达-11,13-二烯-15,16-内酯、（4S,11S）-11-乙酰氧基-8β,19-二羟基-6α-惕各酰氧基-4,18-环氧-新克罗达-13-烯-15,16-内酯以及（4S）-19-乙酰氧基-8β-羟基-6α,7β-二苯甲酰氧基-4,18-环氧-新克罗达-11,13-二烯-15,16-内酯。