半枝莲中的两种新克罗烷二萜类化合物。
Two new neo-clerodane diterpenoids from Scutellaria barbata.
作者信息
Dai Sheng-Jun, Shen Li, Ren Yan
机构信息
School of Pharmaceutical Science, Yantai University, Yantai 264005, China.
出版信息
J Integr Plant Biol. 2008 Jun;50(6):699-702. doi: 10.1111/j.1744-7909.2008.00672.x.
Two new neo-clerodane diterpenoids, 6,7-dibenzoyloxybarbatin C (1, named barbatin D) and 6-(2-acetoxy-3-methylbutanoloxy)-7-(2-carbonyl-3-methylbutanoyloxy) barbatin C (2, named barbatin E) were isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated by spectroscopic methods including extensive 1D and 2D NMR analyses. In vitro, compounds 1-2 showed cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC(50) values in the range of 3.5-6.7 microM.
从半枝莲（Scutellaria barbata D. Don）全草中分离得到两个新的新克罗烷二萜类化合物，6,7-二苯甲酰氧基半枝莲素C（1，命名为半枝莲素D）和6-(2-乙酰氧基-3-甲基丁醇氧基)-7-(2-羰基-3-甲基丁酰氧基)半枝莲素C（2，命名为半枝莲素E）。通过包括广泛的一维和二维核磁共振分析在内的光谱方法阐明了它们的结构。在体外，化合物1-2对三种人类癌细胞系，即HONE-1鼻咽癌、KB口腔表皮样癌和HT29结肠癌细胞显示出细胞毒性活性，IC(50)值在3.5-6.7 microM范围内。
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