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Ibogaine: a review.

作者信息

Alper K R

机构信息

Departments of Psychiatry and Neurology, New York University School of Medicine, New York, NY 10016, USA.

出版信息

Alkaloids Chem Biol. 2001;56:1-38. doi: 10.1016/s0099-9598(01)56005-8.

DOI:10.1016/s0099-9598(01)56005-8
PMID:11705103
Abstract
摘要

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Modulation of the effects of rewarding drugs by ibogaine.伊博格碱对成瘾性药物作用的调节
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The ibogaine medical subculture.伊博格碱医学亚文化。
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Oxa-Iboga alkaloids lack cardiac risk and disrupt opioid use in animal models.羟考酮-Iboga 生物碱缺乏心脏风险，并在动物模型中破坏阿片类药物的使用。
Nat Commun. 2024 Sep 20;15(1):8118. doi: 10.1038/s41467-024-51856-y.
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Ibogaine administration following repeated morphine administration upregulates myelination markers 2', 3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin basic protein (MBP) mRNA and protein expression in the internal capsule of Sprague Dawley rats.
在重复给予吗啡后给予伊波加因，可上调斯普拉格-道利大鼠内囊区髓鞘形成标志物2',3'-环核苷酸3'-磷酸二酯酶（CNP）和髓鞘碱性蛋白（MBP）的mRNA及蛋白表达。
Front Neurosci. 2024 Jul 24;18:1378841. doi: 10.3389/fnins.2024.1378841. eCollection 2024.
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Current Perspectives on the Clinical Research and Medicalization of Psychedelic Drugs for Addiction Treatments: Safety, Efficacy, Limitations and Challenges.当前对迷幻药物治疗成瘾的临床研究和医学化的观点：安全性、疗效、局限性和挑战。
CNS Drugs. 2024 Oct;38(10):771-789. doi: 10.1007/s40263-024-01101-3. Epub 2024 Jul 20.
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Ibogaine Induces Cardiotoxic Necrosis in Rats-The Role of Redox Processes.伊博加因诱导大鼠心脏毒性坏死——氧化还原过程的作用。
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Natural L-type calcium channels antagonists from Chinese medicine.来自中药的天然L型钙通道拮抗剂。
Chin Med. 2024 May 21;19(1):72. doi: 10.1186/s13020-024-00944-8.
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Magnesium-ibogaine therapy in veterans with traumatic brain injuries.镁-伊博加因疗法治疗创伤性脑损伤退伍军人。
Nat Med. 2024 Feb;30(2):373-381. doi: 10.1038/s41591-023-02705-w. Epub 2024 Jan 5.
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Case report: Ibogaine reduced severe neuropathic pain associated with a case of brachial plexus nerve root avulsion.病例报告：伊博格碱减轻了与一例臂丛神经根撕脱相关的严重神经性疼痛。
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Three Naturally-Occurring Psychedelics and Their Significance in the Treatment of Mental Health Disorders.三种天然存在的致幻剂及其在精神健康障碍治疗中的意义。
Front Pharmacol. 2022 Jun 28;13:927984. doi: 10.3389/fphar.2022.927984. eCollection 2022.
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Drug Transporters ABCB1 (P-gp) and OATP, but not Drug-Metabolizing Enzyme CYP3A4, Affect the Pharmacokinetics of the Psychoactive Alkaloid Ibogaine and its Metabolites.药物转运体ABCB1（P-糖蛋白）和有机阴离子转运多肽（OATP），而非药物代谢酶CYP3A4，影响精神活性生物碱伊博格碱及其代谢产物的药代动力学。
Front Pharmacol. 2022 Mar 4;13:855000. doi: 10.3389/fphar.2022.855000. eCollection 2022.