Sheppard S G
J Subst Abuse Treat. 1994 Jul-Aug;11(4):379-85. doi: 10.1016/0740-5472(94)90049-3.
A naturally occurring substance, ibogaine, was taken by seven individuals who were addicted to opiates. Ibogaine, an alkaloid with psychotropic effects at doses of 200-300 mg and above, was taken in single doses of 700-1800 mg by the subjects in the study. At the end of the 24-38-hr psychoactive period induced by the drug at these doses, none of the subjects displayed significant opiate withdrawal symptoms. At the lowest dose of 700 mg, one subject recontinued his drug abuse after 2 days; of the remaining six individuals who took 1,000 mg or above, two relapsed after a number of weeks, one reverted to intermittent heroin use, and three appear to have remained drug-free 14 weeks or more after undergoing this experimental treatment. Ibogaine may be of value in the present and could serve as a model for the development of improved agents for the treatment of substance abuse in the future.
七名阿片类药物成瘾者服用了一种天然存在的物质——伊博格碱。伊博格碱是一种生物碱，剂量在200 - 300毫克及以上时具有精神活性作用，研究中的受试者单次服用剂量为700 - 1800毫克。在这些剂量的药物诱导的24 - 38小时精神活性期结束时，没有一名受试者出现明显的阿片类药物戒断症状。在最低剂量700毫克时，一名受试者在两天后重新开始滥用药物；其余六名服用1000毫克及以上剂量的人中，两人在数周后复发，一人恢复间歇性使用海洛因，三人在接受这种实验性治疗后14周或更长时间似乎一直未再吸毒。伊博格碱目前可能具有价值，并且可以作为未来开发改进的药物滥用治疗药物的模型。
