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来自中药的天然L型钙通道拮抗剂。

Natural L-type calcium channels antagonists from Chinese medicine.

作者信息

Xu Fangfang, Cai Wanna, Liu Bo, Qiu Zhenwen, Zhang Xiaoqi

机构信息

The Second Clinical College , Guangzhou University of Chinese Medicine, Guangzhou, 510006, People's Republic of China.

The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People's Republic of China.

出版信息

Chin Med. 2024 May 21;19(1):72. doi: 10.1186/s13020-024-00944-8.

DOI:10.1186/s13020-024-00944-8
PMID:38773596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11107034/
Abstract

L-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca influx during extracellular excitation. LTCCs are widely present in excitable cells, especially cardiac and cardiovascular smooth muscle cells, and participate in various Ca-dependent processes. LTCCs have been considered as worthy drug target for cardiovascular, neurological and psychological diseases for decades. Natural products from Traditional Chinese medicine (TCM) have shown the potential as new drugs for the treatment of LTCCs related diseases. In this review, the basic structure, function of LTCCs, and the related human diseases caused by structural or functional abnormalities of LTCCs, and the natural LTCCs antagonist and their potential usages were summarized.

摘要

L型钙通道（LTCCs）是电压门控钙通道（VGCCs）最大的亚家族，是细胞外兴奋期间钙离子内流的主要通道。LTCCs广泛存在于可兴奋细胞中，尤其是心脏和心血管平滑肌细胞，并参与各种钙依赖性过程。几十年来，LTCCs一直被认为是治疗心血管、神经和心理疾病的理想药物靶点。中药中的天然产物已显示出作为治疗LTCCs相关疾病新药的潜力。本文综述了LTCCs的基本结构、功能，以及由LTCCs结构或功能异常引起的相关人类疾病，以及天然LTCCs拮抗剂及其潜在用途。

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Calcium Channel Blocker Overdose.钙通道阻滞剂过量
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Functional and Histological Changes in Umbilical Artery and Myometrium Isolated from IUGR Complicated Pregnancies.从 IUGR 合并妊娠中分离出的脐动脉和子宫肌的功能和组织学变化。
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