Leyden J, Kaidbey K, Levy S F
Department of Dermatology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Am J Clin Dermatol. 2001;2(4):263-6. doi: 10.2165/00128071-200102040-00007.
Isolates of Propionibacterium acnes resistant to one or more anti-acne antibiotics (most commonly erythromycin) are being increasingly reported, and the emergence of resistant strains can be associated with therapeutic failure of topical treatment.
Comparison of the in vivo effectiveness of the combination of clindamycin 1% plus benzoyl peroxide 5% in a gel formulation to that of each of 3 clindamycin 1% preparations (gel, lotion, and solution) with respect to reduction in counts of P. acnes cultured from the foreheads of healthy volunteers.
The effects of treatment with the 4 study drugs were compared in an open-label study. Cultures were collected before, after 1 week and after 2 weeks of treatment.
Treatment with the combination formulation resulted in a 99.8% (> 2 logs) reduction in total propionibacterial numbers after 1 week of therapy compared with 30 to 62% (< 1 log) decreases for the different formulations of topical clindamycin alone. By the end of week 2, the combination had decreased P. acnes counts by more than 99.9% (> 3 logs) relative to reductions of from 88 to 95% (< or > 1 log) for the single agent formulations.
Under the conditions of the present study, the combination of clindamycin 1% plus benzoyl peroxide 5% gel produced more rapid and highly significant reductions in P. acnes compared with formulations containing clindamycin alone.
痤疮丙酸杆菌对一种或多种抗痤疮抗生素（最常见的是红霉素）耐药的分离株报道日益增多，耐药菌株的出现可能与局部治疗的治疗失败有关。
比较1%克林霉素加5%过氧化苯甲酰凝胶制剂与3种1%克林霉素制剂（凝胶、洗剂和溶液）在降低健康志愿者前额痤疮丙酸杆菌培养计数方面的体内有效性。
在一项开放标签研究中比较了4种研究药物的治疗效果。在治疗前、治疗1周后和2周后采集培养物。
与单独使用不同剂型的局部克林霉素治疗后减少30%至62%（<1个对数）相比，联合制剂治疗1周后丙酸杆菌总数减少了99.8%（>2个对数）。到第2周结束时，联合制剂使痤疮丙酸杆菌计数减少了99.9%以上（>3个对数），而单一制剂的减少幅度为88%至95%（<或>1个对数）。
在本研究条件下，与单独含克林霉素的制剂相比，1%克林霉素加5%过氧化苯甲酰凝胶联合制剂能更快、更显著地减少痤疮丙酸杆菌。
