Gold Michael H
Gold Skin Care Center and Tennessee Clinical Research Center, Nashville, Tennessee.
J Clin Aesthet Dermatol. 2009 May;2(5):44-8.
The treatment of acne with combination therapy is commonplace with treatment aimed at sustained efficacy with minimal side effects, maximum adherence, and the avoidance of bacterial resistance. Combinations containing clindamycin and benzoyl peroxide have been shown to be effective, but the irritation caused by the concentration of benzoyl peroxide 5% in the more commonly used, fixed combinations can be limiting. In addition, surfactants, preservatives, and high levels of organic solvents, including alcohols, often used in combination with benzoyl peroxide, are potential irritants. An optimized formulation of clindamycin and benzoyl peroxide using a lower concentration of benzoyl peroxide (clindamycin-benzoyl peroxide 2.5% gel) has been developed without the use of surfactants or alcohol. It was recently introduced for the once-daily treatment of inflammatory and noninflammatory lesions in moderate-to-severe acne. Following a clinical program that studied more than 2,800 patients, clindamycin-benzoyl peroxide 2.5% was found to be highly effective and well tolerated. This review highlights the development of clindamycin-benzoyl peroxide 2.5% gel and the data from clinical trials.(J Clin Aesthetic Dermatol. 2009;2(5):44-48.).
痤疮联合治疗很常见，其治疗目标是疗效持久、副作用最小、依从性最高且避免细菌耐药。含克林霉素和过氧化苯甲酰的联合用药已被证明有效，但在更常用的固定组合中，5%浓度的过氧化苯甲酰所引起的刺激可能会有局限性。此外，通常与过氧化苯甲酰联合使用的表面活性剂、防腐剂以及高浓度有机溶剂（包括酒精）都是潜在的刺激物。已研发出一种优化配方的克林霉素和过氧化苯甲酰制剂，使用较低浓度的过氧化苯甲酰（克林霉素 - 过氧化苯甲酰2.5%凝胶），且未使用表面活性剂或酒精。它最近被用于中重度痤疮炎性和非炎性皮损的每日一次治疗。在一项对2800多名患者进行研究的临床项目之后，发现克林霉素 - 过氧化苯甲酰2.5%凝胶疗效显著且耐受性良好。本综述重点介绍了克林霉素 - 过氧化苯甲酰2.5%凝胶的研发情况以及临床试验数据。（《临床美容皮肤病学杂志》。2009年；2(5):44 - 48。）
