Makinodan T, Heidrick M L, Nordin A A
Birth Defects Orig Artic Ser. 1975;11(1):193-8.
In general, both cell-mediated and humoral immune activities decline with advancing age and, associated with this decline, is an increase in the incidence of certain types of autoimmune disease, cancer and infection. Not only may the relationship be causal, but the former may be a significant factor involved in the expression of the latter. Discussion is focused primarily on the relative contribution of extrinsic and intrinsic factors responsible for the immunodeficiency of aging individuals.
一般来说，细胞介导免疫和体液免疫活动都会随着年龄的增长而衰退，与此衰退相关的是，某些类型的自身免疫性疾病、癌症和感染的发病率会增加。这种关系不仅可能是因果关系，而且前者可能是后者表现所涉及的一个重要因素。讨论主要集中在导致衰老个体免疫缺陷的外在因素和内在因素的相对作用上。
