老年人的体液免疫反应：单核细胞对自发斑块形成细胞生成的抑制作用。
Humoral immune response in aged humans: suppressor effect of monocytes on spontaneous plaque forming cell generation.
作者信息
Antonaci S, Jirillo E, Lucivero G, Gallitelli M, Garofalo A R, Bonomo L
出版信息
Clin Exp Immunol. 1983 May;52(2):387-92.
In 50 old donors antibody synthesis has been detected using a protein A haemolytic plaque assay. Data provide evidence that the plaque forming cell (PFC) capacity of aged peripheral mononuclear cells (PBMC) is significantly depressed (0 . 01 greater than P greater than 0 . 001) in comparison to controls. Additionally, suppression is mediated by adherent cells, since monocyte depleted lymphocytes regain the ability of generating spontaneous plaques. The inhibitory effect of monocytes seems to be prostaglandin-dependent, since indomethacin pre-treated PBMC give rise to a normal number of plaques when compared to young mononuclear cells.
在50名老年供体中，通过蛋白A溶血空斑试验检测到了抗体合成。数据表明，与对照组相比，老年外周血单个核细胞（PBMC）的空斑形成细胞（PFC）能力显著降低（0.01＞P＞0.001）。此外，抑制作用由黏附细胞介导，因为去除单核细胞的淋巴细胞恢复了产生自发空斑的能力。单核细胞的抑制作用似乎依赖于前列腺素，因为与年轻单核细胞相比，吲哚美辛预处理的PBMC产生的空斑数量正常。
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