Suppr超能文献

老年人的体液免疫反应：单核细胞对自发斑块形成细胞生成的抑制作用。

Humoral immune response in aged humans: suppressor effect of monocytes on spontaneous plaque forming cell generation.

作者信息

Antonaci S, Jirillo E, Lucivero G, Gallitelli M, Garofalo A R, Bonomo L

出版信息

Clin Exp Immunol. 1983 May;52(2):387-92.

PMID:6222855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1535835/
Abstract

In 50 old donors antibody synthesis has been detected using a protein A haemolytic plaque assay. Data provide evidence that the plaque forming cell (PFC) capacity of aged peripheral mononuclear cells (PBMC) is significantly depressed (0 . 01 greater than P greater than 0 . 001) in comparison to controls. Additionally, suppression is mediated by adherent cells, since monocyte depleted lymphocytes regain the ability of generating spontaneous plaques. The inhibitory effect of monocytes seems to be prostaglandin-dependent, since indomethacin pre-treated PBMC give rise to a normal number of plaques when compared to young mononuclear cells.

摘要

在50名老年供体中，通过蛋白A溶血空斑试验检测到了抗体合成。数据表明，与对照组相比，老年外周血单个核细胞（PBMC）的空斑形成细胞（PFC）能力显著降低（0.01＞P＞0.001）。此外，抑制作用由黏附细胞介导，因为去除单核细胞的淋巴细胞恢复了产生自发空斑的能力。单核细胞的抑制作用似乎依赖于前列腺素，因为与年轻单核细胞相比，吲哚美辛预处理的PBMC产生的空斑数量正常。

相似文献

1
Humoral immune response in aged humans: suppressor effect of monocytes on spontaneous plaque forming cell generation.老年人的体液免疫反应：单核细胞对自发斑块形成细胞生成的抑制作用。
Clin Exp Immunol. 1983 May;52(2):387-92.
2
Distinct role of neonatal and adult monocytes in the regulation of the in vitro antigen-induced plaque-forming cell response in man.新生儿和成人单核细胞在体外人抗原诱导的空斑形成细胞反应调节中的不同作用。
J Immunol. 1984 Oct;133(4):1902-8.
3
Impaired primary in-vitro antibody response in progressive systemic sclerosis patients: rôle of suppressor monocytes.进行性系统性硬化症患者体外初级抗体反应受损：抑制性单核细胞的作用。
Clin Exp Immunol. 1982 Jan;47(1):147-54.
4
Clinical evaluation of B cell and T-regulator cell function using a protein A haemolytic plaque assay.使用蛋白A溶血空斑试验对B细胞和T调节细胞功能进行临床评估。
Clin Exp Immunol. 1981 Oct;46(1):196-205.
5
Antigen-specific suppressor cell activity in patients with scleroderma.
J Rheumatol. 1981 Sep-Oct;8(5):747-51.
6
[Antibody response in cultures of lymphocytes from patients with Hodgkin's lymphoma: role of monocytes].[霍奇金淋巴瘤患者淋巴细胞培养中的抗体反应：单核细胞的作用]
Boll Ist Sieroter Milan. 1987;66(3):214-21.
7
Suppressor T cell activation by human leukocyte interferon.人白细胞干扰素对抑制性T细胞的激活作用。
J Immunol. 1983 Nov;131(5):2301-6.
8
Studies on lymphocyte hyporesponsiveness in cirrhosis: the role of increased monocyte suppressor cell activity.肝硬化患者淋巴细胞低反应性的研究：单核细胞抑制细胞活性增强的作用。
Gastroenterology. 1982 Feb;82(2):206-12.
9
Mechanism of suppression of the depressed lymphocyte response in lung cancer patients.肺癌患者淋巴细胞反应受抑制的机制
Allergol Immunopathol (Madr). 1985 May-Jun;13(3):213-9.
10
Monocyte-mediated regulation of cellular immunity in humans: loss of suppressor activity with ageing.人类单核细胞介导的细胞免疫调节：随着年龄增长抑制活性丧失。
Clin Exp Immunol. 1981 Aug;45(2):439-46.

引用本文的文献

1
In vitro effects of human lipoproteins on the immune system in healthy donors: inhibition of plaque forming cell generation and decreased frequency of NK cells.人脂蛋白对健康供体免疫系统的体外作用：抑制噬斑形成细胞生成并降低自然杀伤细胞频率。
Clin Exp Immunol. 1984 Jun;56(3):677-82.

本文引用的文献

1
The dual effect of prostaglandin (PGE2) and ethanol on the natural killer cytolytic process: effector activation and NK-cell-target cell conjugate lytic inhibition.前列腺素（PGE2）和乙醇对自然杀伤细胞溶解过程的双重作用：效应细胞激活和NK细胞-靶细胞共轭溶解抑制。
J Immunol. 1980 Dec;125(6):2770-7.
2
Age dependence of subpopulations and functions of human peripheral lymphocytes.人类外周淋巴细胞亚群及功能的年龄依赖性
J Clin Lab Immunol. 1981 Jan;5(1):47-51.
3
Decreased in vitro humoral immune responses in aged humans.老年人体外体液免疫反应降低。
J Clin Invest. 1981 Apr;67(4):1094-102. doi: 10.1172/jci110122.
4
Age-related impairment of the in vitro antibody response in the human.人类体外抗体反应的年龄相关损伤。
Clin Exp Immunol. 1980 Jan;39(1):208-14.
5
In vitro modulation of cell-mediated immunity by prostaglandin E2. I. Enhancing-inhibitory effects on antibody-dependent cellular cytotoxicity.前列腺素E2对细胞介导免疫的体外调节作用。I. 对抗体依赖性细胞毒性的增强-抑制作用
Prostaglandins Leukot Med. 1982 Sep;9(3):285-93. doi: 10.1016/s0262-1746(82)80015-2.
6
In vitro modulation of cell-mediated immunity by prostaglandin E2. II. Enhancement of spontaneous plaque-forming cell generation.前列腺素E2对细胞介导免疫的体外调节作用。II. 增强自发噬斑形成细胞的生成
Prostaglandins Leukot Med. 1982 Sep;9(3):295-300. doi: 10.1016/s0262-1746(82)80016-4.
7
Spontaneous reverse hemolytic plaque formation. III. Monocyte-mediated suppression of elevated plaque formation in autoimmune disease.自发性反向溶血空斑形成。III. 单核细胞介导的自身免疫性疾病中升高的空斑形成抑制作用。
Clin Immunol Immunopathol. 1982 Sep;24(3):386-95. doi: 10.1016/0090-1229(82)90009-5.
8
Abolished in vitro antibody response in elderly: exclusive involvement of prostaglandin-induced T suppressor cells.老年人体外抗体反应的消除：前列腺素诱导的T抑制细胞的单独作用。
Clin Immunol Immunopathol. 1982 Sep;24(3):377-85. doi: 10.1016/0090-1229(82)90008-3.
9
Characterization of immunoregulatory T lymphocytes during ageing by monoclonal antibodies.利用单克隆抗体对衰老过程中的免疫调节性T淋巴细胞进行表征。
Clin Exp Immunol. 1982 Apr;48(1):148-54.
10
Interferon alpha modulates an inverse relationship between mitogenesis and antibody synthesis on human peripheral blood lymphocytes (PBL).α干扰素可调节人外周血淋巴细胞（PBL）有丝分裂与抗体合成之间的负相关关系。
Cell Immunol. 1982 Jul 15;71(1):208-9. doi: 10.1016/0008-8749(82)90510-x.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验