Muratani T, Akasaka S, Kobayashi T, Yamada Y, Inatomi H, Takahashi K, Matsumoto T
Department of Urology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Japan.
Antimicrob Agents Chemother. 2001 Dec;45(12):3603-6. doi: 10.1128/AAC.45.12.3603-3606.2001.
We have previously reported that the Neisseria gonorrhoeae isolates from clinical failure cases treated with cefdinir and aztreonam, beta-lactams exhibited high MICs. These resistant isolates were clearly separated from the isolates exhibiting a low level of resistance to beta-lactams as shown by the MIC distribution of cefozopran. Restriction fragment length polymorphism DNA typing revealed that the outbreak of cefozopran-resistant isolates in Kitakyushu, Japan, occurred as a result of clonal spread.
我们之前曾报道，从接受头孢地尼和氨曲南治疗的临床失败病例中分离出的淋病奈瑟菌，β-内酰胺类药物显示出高最低抑菌浓度（MIC）。这些耐药菌株与对β-内酰胺类药物耐药水平较低的菌株明显不同，如头孢唑肟的MIC分布所示。限制性片段长度多态性DNA分型显示，日本北九州头孢唑肟耐药菌株的爆发是克隆传播的结果。
