脑膜炎奈瑟菌对青霉素敏感性的非培养法预测
Nonculture prediction of Neisseria meningitidis susceptibility to penicillin.
作者信息
Antignac A, Alonso J M, Taha M K
机构信息
Unité des Neisseria, Centre National de Référence des Méningocoques, Institut Pasteur, 75724 Paris Cedex 15, France.
出版信息
Antimicrob Agents Chemother. 2001 Dec;45(12):3625-8. doi: 10.1128/AAC.45.12.3625-3628.2001.
Abstract
We developed a nonculture method to predict the susceptibility of Neisseria meningitidis to penicillin G. The penA gene was amplified and submitted to restriction fragment length polymorphism analysis. This approach was first validated with a collection of 75 meningococcal strains of known phenotypes. It was next successfully applied to 29 clinical samples.
摘要
我们开发了一种非培养方法来预测脑膜炎奈瑟菌对青霉素G的敏感性。扩增penA基因并进行限制性片段长度多态性分析。该方法首先用75株已知表型的脑膜炎球菌菌株进行验证。接下来，它成功应用于29份临床样本。
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