Central catecholamine receptor blocking actions of BE-2254 ('heat'): comparison with chlorpromazine and haloperidol.
作者信息
Clineschmidt B V, Pflueger A B, Bunting P R, McGuffin J C, Ballentine R J
出版信息
Eur J Pharmacol. 1975 Jun-Jul;32(02):279-86. doi: 10.1016/0014-2999(75)90294-0.
PMID:1171016
Abstract
BE-2254, 2-[beta-(4-hydroxyphenyl)-ethylaminomethyl]-tetralone, (ED50 = 3.4 mg/kg i.p.) was about equal to chlorpromazine (ED50 = 4.4) as an antagonist of central noradrenergic receptor stimulation produced by clonidine (enhancement of the flexor reflex in spinalized rats). Haloperidol and phentolamine had essentially no effect at 9 mg/kg i.p...
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