Animal models of chronic obstructive pulmonary disease.
作者信息
Dawkins P A, Stockley R A
机构信息
Lung Investigation Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK.
出版信息
Thorax. 2001 Dec;56(12):972-7. doi: 10.1136/thorax.56.12.972.
Abstract
摘要
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EXPERIMENTAL EMPHYSEMA: ITS PRODUCTION WITH PAPAIN IN NORMAL AND SILICOTIC RATS.实验性肺气肿：木瓜蛋白酶在正常和矽肺大鼠中诱导产生肺气肿的研究
Arch Environ Health. 1965 Jul;11:50-8. doi: 10.1080/00039896.1965.10664169.
2
Models for gain-of-function and loss-of-function of MMPs. Transgenic and gene targeted mice.基质金属蛋白酶功能获得和功能丧失模型。转基因小鼠和基因敲除小鼠。
Methods Mol Biol. 2001;151:149-79. doi: 10.1385/1-59259-046-2:149.
3
Interferon gamma induction of pulmonary emphysema in the adult murine lung.成年小鼠肺中γ干扰素诱导的肺气肿
J Exp Med. 2000 Dec 4;192(11):1587-600. doi: 10.1084/jem.192.11.1587.
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Inhibition of VEGF receptors causes lung cell apoptosis and emphysema.抑制血管内皮生长因子受体可导致肺细胞凋亡和肺气肿。
J Clin Invest. 2000 Dec;106(11):1311-9. doi: 10.1172/JCI10259.
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Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema.将白细胞介素-13诱导靶向至成年肺会导致基质金属蛋白酶和组织蛋白酶依赖性肺气肿。
J Clin Invest. 2000 Nov;106(9):1081-93. doi: 10.1172/JCI10458.
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Loop-sheet polymerization: the mechanism of alpha1-antitrypsin deficiency.环状片层聚合：α1抗胰蛋白酶缺乏症的机制
Respir Med. 2000 Aug;94 Suppl C:S3-6. doi: 10.1053/rmed.2000.0850.
7
BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis.BLTR介导白三烯B4诱导的趋化作用和黏附作用，并且在腹膜炎小鼠模型中嗜酸性粒细胞积聚过程中起主导作用。
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Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.对白三烯B(4)受体进行靶向破坏的小鼠实验揭示了其在炎症及血小板活化因子诱导的过敏反应中的作用。
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Disruption of the klotho gene causes pulmonary emphysema in mice. Defect in maintenance of pulmonary integrity during postnatal life.klotho基因的破坏会导致小鼠患肺气肿。出生后肺部完整性维持存在缺陷。
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