Department of Respiratory and Critical Care Medicine, Second Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
State Key Lab of Respiratory Disease, Guangzhou, China.
J Immunol Res. 2017;2017:7915975. doi: 10.1155/2017/7915975. Epub 2017 Apr 23.
Chronic obstructive pulmonary disease (COPD) is a major cause of mortality worldwide, which is characterized by chronic bronchitis, destruction of small airways, and enlargement/disorganization of alveoli. It is generally accepted that the neutrophilic airway inflammation observed in the lungs of COPD patients is intrinsically linked to the tissue destruction and alveolar airspace enlargement, leading to disease progression. Animal models play an important role in studying the underlying mechanisms of COPD as they address questions involving integrated whole body responses. This review aims to summarize the current animal models of COPD, focusing on their advantages and disadvantages on immune responses and neutrophilic inflammation. Also, we propose a potential new animal model of COPD, which may mimic the most characteristics of human COPD pathogenesis, including persistent moderate-to-high levels of neutrophilic inflammation.
慢性阻塞性肺疾病（COPD）是全球主要的致死原因，其特征为慢性支气管炎、小气道破坏和肺泡扩大/结构紊乱。人们普遍认为，COPD 患者肺部观察到的中性粒细胞气道炎症与组织破坏和肺泡气腔扩大有关，导致疾病进展。动物模型在研究 COPD 的潜在机制方面发挥着重要作用，因为它们可以解决涉及全身综合反应的问题。本综述旨在总结 COPD 的现有动物模型，重点关注它们在免疫反应和中性粒细胞炎症方面的优缺点。此外，我们提出了一种潜在的 COPD 新动物模型，该模型可能模拟人类 COPD 发病机制的大多数特征，包括持续的中高水平中性粒细胞炎症。
