体液因子在细胞毒性药物诱导的骨髓抑制过程中对造血调控的作用。
Role of humoral factors in the regulation of hemopoiesis during cytostatic-induced myelosuppression.
作者信息
Dygai A M, Zhdanov V V, Simanina E V, Gur'yantseva L A, Udut E V, Khrichkova T Yu, Kirienkova E V, Epstein O I, Gol'dberg E D
机构信息
Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
出版信息
Bull Exp Biol Med. 2003 Jun;135(6):548-51. doi: 10.1023/a:1025469000276.
The content of hemopoietic precursors in the bone marrow, its morphological composition, production of hemopoietic growth factors by cells of the hemopoietic microenvironment, erythropoietic activity, and plasma content of endogenous erythropoietin were studied in CBA/CaLac mice with hypoplasia of hemopoiesis induced by adriamycin in a maximum permissible dose. Cytostatic treatment affected production of substances determining erythropoietic activity by adherent and nonadherent cells of the bone marrow. Erythropoietic activity of peripheral blood plasma considerably increased. Recovery of erythroid hemopoiesis was determined by the effects of endogenous erythropoietin and other substances secreted by cells of the hemopoietic microenvironment and present in the peripheral blood.
研究了用最大允许剂量阿霉素诱导造血功能低下的CBA/CaLac小鼠骨髓中造血前体细胞的含量、其形态组成、造血微环境细胞产生造血生长因子的情况、红细胞生成活性以及内源性促红细胞生成素的血浆含量。细胞抑制治疗影响骨髓贴壁细胞和非贴壁细胞产生决定红细胞生成活性的物质。外周血血浆的红细胞生成活性显著增加。红细胞系造血的恢复取决于内源性促红细胞生成素和造血微环境细胞分泌并存在于外周血中的其他物质的作用。
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