Free radical oxidation and activity of enzymes catalyzing biotransformation of xenobiotics in the liver of rats with experimental acute pancreatitis.
作者信息
Shabanov V I, Sarbaeva N N, Milyakova M N, Detyuchenko V P
机构信息
Department of Surgery, Samara Military Medical Institute.
出版信息
Bull Exp Biol Med. 2001 Aug;132(2):754-6. doi: 10.1023/a:1013077811544.
PMID:11713557
Abstract
The development of experimental acute pancreatitis in rats was accompanied by intensification of lipid peroxidation, activation of superoxide dismutase and glutathione reductase, inhibition of glutathione transferase, and deceleration of aniline N-hydroxylation by cytochrome P-450 in the liver. Antioxidants inhibited lipid peroxidation and antioxidant enzymes, but did not prevent inhibition of detoxifying enzymes.
摘要
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