Shabanov V I, Sarbaeva N N, Milyakova M N, Detyuchenko V P
Department of Surgery, Samara Military Medical Institute.
Bull Exp Biol Med. 2001 Aug;132(2):754-6. doi: 10.1023/a:1013077811544.
The development of experimental acute pancreatitis in rats was accompanied by intensification of lipid peroxidation, activation of superoxide dismutase and glutathione reductase, inhibition of glutathione transferase, and deceleration of aniline N-hydroxylation by cytochrome P-450 in the liver. Antioxidants inhibited lipid peroxidation and antioxidant enzymes, but did not prevent inhibition of detoxifying enzymes.
大鼠实验性急性胰腺炎的发展伴随着脂质过氧化的增强、超氧化物歧化酶和谷胱甘肽还原酶的激活、谷胱甘肽转移酶的抑制以及肝脏中细胞色素P-450介导的苯胺N-羟基化的减速。抗氧化剂抑制脂质过氧化和抗氧化酶，但不能防止解毒酶的抑制。
