Okano H, Shiraki K, Inoue H, Deguchi M, Sugimoto K, Sakai T, Ohmori S, Murata K, Nakano T, Yamakado K, Takeda K
First Department of Internal Medicine, Mie University School of Medicine, Tsu 514-8507, Japan.
Int J Oncol. 2001 Dec;19(6):1279-82. doi: 10.3892/ijo.19.6.1279.
We performed interventional treatments on 50 patients with hepatocellular carcinoma (HCC) and analyzed the relationship between these treatments and the exacerbation of liver function after treatment. The different treatments included transcatheter arterial embolization (TAE), percutaneous ethanol injection therapy (PEIT), selective segmental sclerotherapy (SSS), combined TAE and PEIT, or transcatheter arterial chemo-injection (TAI). Thirteen patients showed an exacerbation of liver function after treatment. The laboratory data on admission, showed the lower levels of serum albumin and cholinesterase in this group. In comparison to patients who did not show any exacerbation of liver function, these 13 patients had undergone combined TAE and PEIT. An analysis of cases after TAE and PEIT treatment revealed that the time from TAE to PEIT was shorter in the exacerbation group than in the non-exacerbation group, however, there was no significant difference in the amount of injected ethanol between the two groups. It is assumed that the values of albumin and cholinesterase before treatment, or the period from TAE to PEIT are related to liver failure after treatment. Combining TAE and PEIT treatment may be effective for HCC, however, we should pay special attention to liver failure after treatment.
我们对50例肝细胞癌（HCC）患者进行了介入治疗，并分析了这些治疗方法与治疗后肝功能恶化之间的关系。不同的治疗方法包括经导管动脉栓塞术（TAE）、经皮乙醇注射疗法（PEIT）、选择性节段硬化疗法（SSS）、TAE与PEIT联合应用或经导管动脉化疗注射（TAI）。13例患者治疗后出现肝功能恶化。入院时的实验室数据显示，该组患者血清白蛋白和胆碱酯酶水平较低。与未出现任何肝功能恶化的患者相比，这13例患者接受了TAE与PEIT联合治疗。对TAE和PEIT治疗后的病例分析显示，肝功能恶化组从TAE到PEIT的时间比未恶化组短，然而，两组之间注射乙醇的量没有显著差异。推测治疗前白蛋白和胆碱酯酶的值，或从TAE到PEIT的时间与治疗后肝衰竭有关。TAE与PEIT联合治疗可能对HCC有效，然而，我们应特别注意治疗后的肝衰竭。
