Statham S, Morgan R A
Clinical Gene Therapy Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-1851, USA.
Curr Opin Mol Ther. 1999 Aug;1(4):430-6.
Despite advances in drug treatment for human immunodeficiency virus (HIV), new therapeutics are needed for sustained treatment of this infection. Gene therapy has great potential for HIV due to its specificity for viral targets and prolonged expression of therapeutics. In this review, the various approaches that current gene therapy clinical trials are using to treat HIV disease are described. Results reported from these trials indicate that the approaches tested appear to be safe and confer some benefit to the genetically-modified cell. However, technical improvements must be made in order for gene therapy to realize its true potential.
尽管人类免疫缺陷病毒（HIV）的药物治疗取得了进展，但仍需要新的疗法来持续治疗这种感染。基因疗法因其对病毒靶点的特异性和治疗药物的延长表达，在治疗HIV方面具有巨大潜力。在这篇综述中，描述了当前基因治疗临床试验用于治疗HIV疾病的各种方法。这些试验报告的结果表明，所测试的方法似乎是安全的，并给基因改造细胞带来了一些益处。然而，为了使基因疗法发挥其真正潜力，必须在技术上加以改进。
