Bowen F P, Kamienny R S, Burns M M, Yahr M
Neurology. 1975 Aug;25(8):701-4. doi: 10.1212/wnl.25.8.701.
Concept formation was compared in 71 parkinsonian patients and 35 controls matched for age and WAIS vebal IQ. It was found that the patients formed significantly fewer concepts, as measured by the Wisconsin Card Sorting Test (WCST). The patients had difficulties in shifting sets and were unable to attend to the completion of a concept. Levodopa-treated patients were able to produce more correct responses, but were still unable to maintain the correct responses to produce more correct concepts than non-levodopa-treated patients. The behavior of the parkinsonian patients on the WCST is similar to that of patients who have undergone frontal lobectomy. In addition, the results indicate that levodopa therapy may improve "vigilance", without increasing the patient's overall cognitive ability.
对71名帕金森病患者和35名年龄及韦氏成人智力量表言语智商相匹配的对照组进行了概念形成方面的比较。结果发现，通过威斯康星卡片分类测验（WCST）测量，患者形成的概念明显较少。患者在转换思维定势方面存在困难，无法专注于完成一个概念。接受左旋多巴治疗的患者能够做出更多正确反应，但与未接受左旋多巴治疗的患者相比，仍无法维持正确反应以形成更多正确概念。帕金森病患者在WCST上的行为与接受额叶切除术的患者相似。此外，结果表明左旋多巴治疗可能会改善“警觉性”，而不会提高患者的整体认知能力。
