Caltagirone C, Carlesimo A, Nocentini U, Vicari S
Clinica Neurologica, II Universitá di Roma, Italy.
J Neurol Neurosurg Psychiatry. 1989 Mar;52(3):334-7. doi: 10.1136/jnnp.52.3.334.
An extensive neuropsychological battery (the Mental Deterioration Battery) was utilized to distinguish, within a sample of 24 idiopathic Parkinsonians, those showing signs of diffuse mental deterioration (n = 9) from those without deterioration (n = 15). Performances of control subjects on a wide range of tests exploring mnesic, visuo-constructive, linguistic and general intellectual functions (n = 21) did not differ from analogous performances of Parkinsonians without signs of diffuse mental deterioration. The Wisconsin Card Sorting Test was then used to verify the hypothesis that a selective impairment of cognitive functions subsumed by the integrity of frontal lobes could be demonstrated in Parkinsonian patients. Our results provide evidence that in this task, defective performances are obtained by Parkinsonians and even by patients without signs of diffuse cognitive impairment. These findings seem to confirm that a deficit in concept formation, maintenance and shifting is largely independent of the dementia frequently noticed in Parkinson's disease.
使用一套广泛的神经心理测试（精神衰退测试组），在24名特发性帕金森病患者样本中，区分出有弥漫性精神衰退迹象的患者（n = 9）和无精神衰退迹象的患者（n = 15）。在一系列探索记忆、视觉建构、语言和一般智力功能的测试中，对照组受试者（n = 21）的表现与无弥漫性精神衰退迹象的帕金森病患者的类似表现并无差异。随后使用威斯康星卡片分类测试来验证这一假设，即帕金森病患者可能存在额叶完整性所包含的认知功能的选择性损害。我们的结果表明，在这项任务中，帕金森病患者甚至无弥漫性认知障碍迹象的患者都表现出缺陷。这些发现似乎证实，概念形成、维持和转换方面的缺陷在很大程度上与帕金森病中经常出现的痴呆无关。
