[2型非胰岛素依赖型糖尿病中载脂蛋白E2与肾功能不全血脂水平的关系]

[The relationship of Apo E2 and renal insufficiency lipid levels in NIDDM].

作者信息

Xiang G, Xia B, He Y

机构信息

Department of Endocrinology, Guangzhou Army Wuhan General Hospital of PLA, Guangzhou 430070.

出版信息

Zhonghua Yi Xue Za Zhi. 1999 May;79(5):339-41.

PMID:11715472

Abstract

OBJECTIVE

To study the relationship of ApoE2 and renal insufficiency, lipid levels in NIDDM patients.

METHODS

PCR/ASO probe technique was used to determine ApoE genotypes. 46 NIDDM patients with renal insufficiency and 84 NIDDM patients without renal insufficiency as well as 50 healthy individuals were selected. Of the patients with renal insufficiency, 10 belonged to ApoE2 and 38 to ApoE3/3. In addition, 57 NIDDM patients with normalbuminuria (6 with ApoE2, 51 with ApoE3/3) were selected from the 84 NIDDM patients without renal insufficiency.

RESULTS

Allele frequency was significantly higher in diabetic patients with renal insufficiency than in diabetic patients without renal insufficiency and in healthy individuals (P < 0.05). Tc, TG levels were significantly higher in ApoE2 group with renal insufficiency than in E3/3 group with renal insufficiency, ApoE3/3 and ApoE2 groups with normoal buminuria. HDL-c level was significantly lower in ApoE2 group with renal insufficiency than in other 3 groups.

CONCLUSION

ApoE2 is associated with renal insufficiency in NIDDM patients and that ApoE2 may be a factor that aggravates lipid abnormalities in NIDDM patients with renal insufficiency.

摘要

目的

研究2型糖尿病（NIDDM）患者载脂蛋白E2（ApoE2）与肾功能不全及血脂水平的关系。

方法

采用聚合酶链反应/等位基因特异性寡核苷酸探针技术（PCR/ASO）检测ApoE基因型。选取46例合并肾功能不全的NIDDM患者、84例未合并肾功能不全的NIDDM患者及50例健康对照者。合并肾功能不全的患者中，10例为ApoE2型，38例为ApoE3/3型。此外，从84例未合并肾功能不全的NIDDM患者中选取57例尿白蛋白正常的患者（其中6例为ApoE2型，51例为ApoE3/3型）。

结果

合并肾功能不全的糖尿病患者的等位基因频率显著高于未合并肾功能不全的糖尿病患者及健康对照者（P<0.05）。合并肾功能不全的ApoE2组总胆固醇（Tc）、甘油三酯（TG）水平显著高于合并肾功能不全的E3/3组、尿白蛋白正常的ApoE3/3组及ApoE2组。合并肾功能不全的ApoE2组高密度脂蛋白胆固醇（HDL-c）水平显著低于其他3组。