载脂蛋白 E 基因多态性与肾脏疾病脂质代谢的关系。
Association of apoE gene polymorphisms with lipid metabolism in renal diseases.
机构信息
Department of Nephrology, the Second Affiliated Hospital of Shantou University Medical College, 515041, Shantou, China.
Department of Nephrology, Huadu District People's Hospital, Southern Medical University, Guangzhou, China.
出版信息
Afr Health Sci. 2020 Sep;20(3):1368-1381. doi: 10.4314/ahs.v20i3.43.
BACKGROUND AND OBJECTIVES
Apolipoprotein E (apoE) plays a central role in the metabolism and homeostasis of lipids. ApoE gene encodes three major isoforms: ε2, ε3 a nd ε4 forming six phenotypes: E2E2, E2E3, E2E4, E3E3, E3E3 and E4E4. Disorders of the lipid metabolism and the homeostasis are frequently coexist in renal diseases. The association between gene polymorphisms of apoE and lipid metabolism were not consistent. This meta-analysis was performed to assess the association between gene polymorphisms of apoE and lipid metabolism in renal diseases.
METHODS
A pre-defined literatures search and selection of eligible relevant investigations were performed to extract and collect data from electronic databases.
RESULTS
Sixteen articles were enrolled for the analysis of association between apoE gene polymorphisms and lipid metabolism. Subjects with E3E4 had a higher total cholesterol (TC) than those with E3E3, and subjects with E2E3 had a lower TC than those with E3E3. Subjects with ε2, had a lower TC than those with ε3 or ε4, and subjects with ε4 had a higher TC than those with, ε3. Subjects with E2E2, E2E3 or E4E4 had a higher triglyceride (TG) than those with E3E3. Subjects with ε4 had a higher TG than those with ε3. Subjects with ε2, had a higher level of TG than those with non-ε2. Subjects with E3E4 had a slightly lower high-density lipoprotein (HDL) than those with E3E3. E3E4 appeared to be associated with lower levels of HDL. Subjects with E2E2, E2E3 had a notably lower low-density lipoprotein (LDL) than those with E3E3. Subjects with ε2, had a lower LDL than those with ε3 or ε4 ApoE gene polymorphisms were not associated with very low-density lipoprotein, and lipoprotein (a) [Lp(a)]. Subjects with E2E3 or E2E4 had higher apoE levels than those with E3E3, and subjects with E4E4 had lower apoE levels than those with E3E3.
CONCLUSION
ApoE gene polymorphisms are associated with the expression of TC, TG HDL, LDL, Lp(a) or apoE.
背景与目的
载脂蛋白 E (apoE) 在脂质代谢和稳态中起着核心作用。apoE 基因编码三种主要的同工型：ε2、ε3 和 ε4，形成六种表型：E2E2、E2E3、E2E4、E3E3、E3E3 和 E4E4。脂质代谢和稳态紊乱在肾脏疾病中常同时存在。apoE 基因多态性与脂质代谢之间的关联并不一致。本荟萃分析旨在评估 apoE 基因多态性与肾脏疾病中脂质代谢之间的关联。
方法
对电子数据库进行了预定义的文献检索和合格相关研究的选择，以提取和收集数据。
结果
纳入了 16 篇文章来分析 apoE 基因多态性与脂质代谢之间的关联。与 E3E3 相比，E3E4 个体的总胆固醇 (TC) 更高，而 E2E3 个体的 TC 更低。与 ε3 或 ε4 相比，ε2 个体的 TC 更低，与 ε3 相比，ε4 个体的 TC 更高。E2E2、E2E3 或 E4E4 个体的甘油三酯 (TG) 高于 E3E3。与 ε3 相比，ε4 个体的 TG 更高。与非 ε2 相比，ε2 个体的 TG 水平更高。与 E3E3 相比，E3E4 个体的高密度脂蛋白 (HDL) 略低。E3E4 似乎与较低的 HDL 水平相关。与 E3E3 相比，E2E2、E2E3 个体的 LDL 水平明显更低。与 ε3 或 ε4 相比，ε2 个体的 LDL 更低。apoE 基因多态性与极低密度脂蛋白 (VLDL) 和脂蛋白 (a) [Lp(a)] 无关。与 E3E3 相比，E2E3 或 E2E4 个体的 apoE 水平更高，而与 E3E3 相比，E4E4 个体的 apoE 水平更低。
结论
apoE 基因多态性与 TC、TG、HDL、LDL、Lp(a) 或 apoE 的表达有关。
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